ArticleScientific reports2019
The relationship between pubertal timing and markers of vascular and cardiac structure and function in men and women aged 60-64 years.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Pubertal timing as a predictor of epigenetic aging and mortality risk in young adulthood.Developmental psychology · 2025Article
- Associations between phenotypes of childhood and adolescent obesity and incident hypertension in young adulthood.International journal of obesity (2005) · 2025Article
- Age at menarche and risk of premature coronary artery disease: results from Iran premature coronary disease (IPAD) study.Archives of gynecology and obstetrics · 2025Article
- Body Mass Index and Hypertension as Mediators of the Association Between Age at Menarche and Subclinical Atherosclerosis: A Sex-Specific Mendelian Randomization Analysis.Journal of the American Heart Association · 2024Article
- Pediatric sex estimation using AI-enabled ECG analysis: influence of pubertal development.NPJ digital medicine · 2024Article
- Associations Between Phenotypes of Childhood and Adolescent Obesity and Incident Hypertension in Young Adulthood.Research square · 2024Article
- Associations of central precocious puberty with blood pressure trajectories: prospective cohort study.Pediatric research · 2024Article
- The influence of somatic maturity on the relationship between the triglyceride/high-density lipoprotein ratio and vascular health in children and adolescents with dyslipidemia.American journal of human biology : the official journal of the Human Biology Council · 2023Article
- Atherosclerosis Prevention in Adolescents with Obesity: The Role of Moderate-Vigorous Physical Activity.International journal of environmental research and public health · 2022Article
- Puberty Timing and Sex-Specific Trajectories of Systolic Blood Pressure: a Prospective Cohort Study.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Childhood growth and development and DNA methylation age in mid-life.Clinical epigenetics · 2021Article
- Investigating the Relationship Between IGF-I, IGF-II, and IGFBP-3 Concentrations and Later-Life Cognition and Brain Volume.The Journal of clinical endocrinology and metabolism · 2021Article
- Puberty timing and markers of cardiovascular structure and function at 25 years: a prospective cohort study.BMC medicine · 2021Article
- Early age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood.Scientific reports · 2021Article
- Adolescent Sport Participation and Age at Menarche in Relation to Midlife Body Composition, Bone Mineral Density, Fitness, and Physical Activity.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Earlier age at menarche has been associated with higher risk of coronary heart disease, but the mechanisms underlying the association remain unclear. We assessed the relationship of pubertal timing, in both men (n = 672) and women (n = 713), with vascular (carotid intima-media thickness (cIMT), pulse wave velocity (PWV)) and cardiac (left ventricular (LV) structure and function) measures recorded at age 60-64 yrs in a British birth cohort study. Regression models found that earlier menarche was associated with higher (more adverse) LV mass, LV end diastolic volume and left atrial volume, but not with other cardiac measures, cIMT or PWV. Associations were attenuated after adjustment for either adult or childhood BMI (e.g. mean difference in LV mass per year later menarche: -4.2 g (95% CI:-7.0,-1.4) reducing to -2.2 g (95% CI:-4.7,0.4) after adjustment for adult BMI). There were no associations among men, despite those fully mature at 15 yrs having higher blood pressure than the least mature group by 10.21 mmHg (95% CI:19.45,0.98). Any effect of pubertal timing on vascular and cardiac structure and function is likely to be small and primarily confounded by pre-pubertal BMI and/or mediated through adult adiposity.
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