ArticleScientific reports2019
Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Pooled it
- Effects of Metabolic Syndrome on Semen Quality and Circulating Sex Hormones: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2020Pooled it
- Aging-related severe hypertension causes prostatic gland atrophy and testicular injury in rats.Scientific reports · 2026Article
- Article
- Long-term effects of sub-chronic exposure to L-NAME on reproductive system of male rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- The consequences of climate change and male reproductive health: A review of the possible impact and mechanisms.Biochemistry and biophysics reports · 2025Review
- Pulmonary Arterial Hypertension-Induced Reproductive Damage: Effects of Combined Physical Training on Testicular and Epididymal Parameters in Rats.Biomedicines · 2025Article
- High-intensity interval training reduces inflammatory mediator levels in the testes of spontaneously hypertensive rats.Animal reproduction · 2025Article
- Effects of Different Application Routes of Ozone on Testicular Tissue in Rats with Spinal Cord Ischemia and Reperfusion Injury.Drug design, development and therapy · 2025Article
- Paternal Contributions to Recurrent Pregnancy Loss: Mechanisms, Biomarkers, and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2024Review
- Systemic alpha-1 adrenergic receptor inhibition reduces sperm damage in adult and aging spontaneously hypertensive rats.Scientific reports · 2024Article
- Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure.Clinical science (London, England : 1979) · 2024Article
- Doppler Examination of the Testicular Artery of Beagle-Breed Dogs from Birth to Puberty.Tomography (Ann Arbor, Mich.) · 2023Article
- An updated insight on testicular hemodynamics: Environmental, physiological, and technical perspectives in farm and companion animals.Veterinary research communications · 2023Review
- Treatment progress of cryptozoospermia with Western Medicine and traditional Chinese medicine: A literature review.Health science reports · 2023Article
- The role of taurine in male reproduction: Physiology, pathology and toxicology.Frontiers in endocrinology · 2023Review
- Association between the prevalence rates of circadian syndrome and testosterone deficiency in US males: data from NHANES (2011-2016).Frontiers in nutrition · 2023Article
- The role of the resistive index in predicting testicular atrophy after orchiopexy in unilateral undescended testis.Pediatric surgery international · 2022Article
- Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction.Clinical science (London, England : 1979) · 2022Article
- Morphological and ultrasonographic characterization of the three zones of supratesticular region of testicular artery in Assaf rams.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arterial hypertension is a cardiovascular disease that leads to important systemic alterations and drastically impairs normal organ function over time. Hypertension affects around 700 million men of reproductive age and hypertensive men present increased risk for reproductive disorders, such as erectile dysfunction. However, the link between arterial hypertension and male reproductive disorders is associative at best. Moreover, many studies have reported associations between decreased male fertility and/or semen quality and alterations to general male health. In this study we aim to investigate the effect of systemic high blood pressure in sperm quality, sperm functional characteristics and testicular physiology in a rat model. Hypertensive rats presented altered testicular morphology - mainly vascular alterations and impaired testicular vasomotion. Hypertensive rats also presented decrease in sperm concentration, DNA integrity and increased percentages of sperm with dysfunctional mitochondria, intracellular superoxide anion activity and abnormal morphology. This study provides mechanistic insights by which arterial hypertension affects the testes, evidencing the testes as another target organ for hypertension as well as its impact on sperm quality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.