Evidence map›Paper›PMID 31363124›Full record

ArticleScientific reports2019

The effect of labor and delivery mode on electrocortical and brainstem autonomic function during neonatal transition.

Sarah B Mulkey, Srinivas Kota, Rathinaswamy B Govindan, Tareq Al-Shargabi, Christopher B Swisher, Augustine Eze, Laura Hitchings, Stephanie Russo, Nicole Herrera, Robert McCarter and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Functional brain network properties of healthy full-term newborns quantified by scalp and source-reconstructed EEG.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Cerebral cortical autonomic connectivity in low-risk term newborns.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Sarah B MulkeyChildren's National Health System, Washington, DC, United States. sbmulkey@childrensnational.org.ORCID http://orcid.org/0000-0002-8084-526X
Srinivas KotaChildren's National Health System, Washington, DC, United States.
Rathinaswamy B GovindanChildren's National Health System, Washington, DC, United States.
Tareq Al-ShargabiChildren's National Health System, Washington, DC, United States.
Christopher B SwisherChildren's National Health System, Washington, DC, United States.
Augustine EzeInova Women's and Children's Hospital, Falls Church, VA, United States.
Laura HitchingsChildren's National Health System, Washington, DC, United States.
Stephanie RussoChildren's National Health System, Washington, DC, United States.
Nicole HerreraChildren's National Health System, Washington, DC, United States.
Robert McCarterChildren's National Health System, Washington, DC, United States.
G Larry MaxwellInova Women's and Children's Hospital, Falls Church, VA, United States.
Robin BakerInova Women's and Children's Hospital, Falls Church, VA, United States.
Adre J du PlessisChildren's National Health System, Washington, DC, United States.
Children's National · USInova Children's Hospital · US

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
Clinical and Translational Science Institute at Childrens National-Mentored Career Development CoreKL2TR001877 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI LUBAN, NAOMI L · 2016 to 2020
$2.0M
NCATS NIH HHS KL2 TR001877NCATS NIH HHS UL1 TR001876NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

Delivery of the newborn occurs either vaginally or via caesarean section. It is not known whether the mode of delivery and exposure to labor affects early autonomic nervous system (ANS) function, as measured by heart rate variability (HRV), or cortical electroencephalogram (EEG) activity. The objective of the study was to determine if autonomic function in newborns differs by mode of delivery. Simultaneous recording of EEG and electrocardiogram were collected in low-risk term newborns at <72 hours of age to measure HRV, the asymmetry index, and EEG power. Newborns were compared by delivery type: vaginal delivery (VD), cesarean section (CS) after labor (L-CS), or elective CS (E-CS). Quantile Regression controlled for gestational age, postnatal age, and percent active states. One hundred and eighteen newborns were studied at 25.2 (11.4) hours of age. Sixty-two (52.5%) were born by VD, 22 by L-CS (18.6%), and 34 by E-CS (28.8%). HRV metrics didn't differ by delivery mode. Asymmetry index was higher in L-CS compared to VD and E-CS (P = 0.03). On EEG, L-CS newborns showed lower relative gamma power compared to VD and E-CS (P = 0.005). The study found that overall ANS tone is not altered by mode of delivery in low-risk term newborns.

Indexed as

AdultAutonomic Nervous SystemBrain StemBrain WavesCerebral CortexDelivery, ObstetricFemaleHumansInfant, NewbornMaleNervous System Diseases

Identifiers

PMID31363124
PMCPMC6667470
OpenAlexW2964942601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.