Evidence map›Paper›PMID 31363115›Full record

ArticleScientific reports2019

Multicentre evaluation of Xpert MTB/RIF assay in detecting urinary tract tuberculosis with urine samples.

Yu Chen, Peng Wu, Liang Fu, Yu-Hong Liu, Yao Zhang, Yanping Zhao

Open access · goldAbstract readEvaluation StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Assessing the diagnostic accuracy of the Xpert MTB/RIF assay in detecting epididymal tuberculosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022
    Article
  6. Article
  7. Comparison of the CapitalBio™Mycobacterium RT-PCR detection test and Xpert MTB/RIF assay for diagnosis of renal tuberculosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Article
  8. Observational
  9. Article
  10. Urogenital Tuberculosis: A Narrative Review and recommendations for diagnosis and treatment.International braz j urol : official journal of the Brazilian Society of Urology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yu ChenShenyang Tenth People's Hospital and Shenyang Chest Hospital, Department of Tuberculosis, Shenyang, Liaoning Province, 110044, P.R. China.
Peng WuSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 1/F, Patrick Manson Building (North), 7 Sassoon Road, Pokfulam, Hong Kong, Special Administrative Region, P.R. China.
Liang FuShenzhen Third People's Hospital affiliated to Southern University of Science and Technology, the 2nd Pulmonary Diseases Department, Shenzhen, Guangdong Province, 518112, P.R. China.
Yu-Hong LiuChina TB Clinical Trial Consortium, Beijing, 101149, P.R. China.
Yao ZhangGlobal Research Services of Family Health International 360, Beijing, 101149, P.R. China.
Yanping ZhaoSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 1/F, Patrick Manson Building (North), 7 Sassoon Road, Pokfulam, Hong Kong, Special Administrative Region, P.R. China. zhaohelen@connect.hku.hk.ORCID http://orcid.org/0000-0002-6806-1593
HKU-Pasteur Research Pole · HKSouthern University of Science and Technology · CNUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genitourinary tuberculosis (GUTB) accounts for up to 40% of extrapulmonary tuberculosis cases. Rapid tests for GUTB are urgently needed because it is often associated with delayed health-care seeking, leading to serious consequences. This study evaluated the performance of the Xpert MTB/RIF assay in the rapid diagnosis of urinary tract tuberculosis (UTB) and rifampicin-resistant tuberculosis with urine specimens. In all, 302 patients were included from four hospitals in China. Suspected UTB patients were tested with Xpert, smear, and MGIT 960 culture. Drug susceptibility testing (DST) was conducted for culture-positive cases. The performance of the assays was evaluated against MGIT 960 culture and a composite reference standard (CRS). Among all participants, 150 (49.7%) had CRS-positive UTB, of whom 36 (24.0%) were culture-confirmed. Against culture, Xpert and smear achieved a sensitivity of 94.4% (95% CI: 81.3-99.3%) and 22.2% (95% CI: 10.1-39.2%), respectively. Against CRS, the sensitivity of Xpert, smear and culture was 41.3% (95% CI: 33.4-49.7%), 7.3% (95% CI: 3.7-12.7%), and 24.0% (95% CI: 17.4-31.6%). Xpert had better performance than smear and culture in detecting UTB from urine samples and could be considered for the diagnosis of UTB. Moreover, Xpert showed better performance than MGIT 960-based DST using urine culture.

Indexed as

AdultAgedAged, 80 and overAntibiotics, AntitubercularDrug Resistance, BacterialFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedMycobacterium tuberculosisRifampinTuberculosis, Female GenitalTuberculosis, Male GenitalTuberculosis, Multidrug-ResistantYoung AdultAntibiotics, AntitubercularRifampin

Identifiers

PMID31363115
PMCPMC6667469
OpenAlexW2966670820

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.