ArticleNature communications2019
Country-wide medical records infer increased allergy risk of gastric acid inhibition.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development.Nature communications · 2020Pooled it
- Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease.JAMA neurology · 2025Article
- Profiling inflammatory outcomes ofmBio · 2024Article
- Gut microbiome features in pediatric food allergy: a scoping review.Frontiers in allergy · 2024Article
- Acid-suppressive medication and incidence of chronic childhood immune-mediated diseases: A scoping review.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2023Article
- Review
- Patients with Obesity and a History of Metformin Treatment Have Lower Influenza Mortality: A Retrospective Cohort Study.Pathogens (Basel, Switzerland) · 2022Article
- Duodenal Dysbiosis and Relation to the Efficacy of Proton Pump Inhibitors in Functional Dyspepsia.International journal of molecular sciences · 2021Article
- Optimizing drug selection from a prescription trajectory of one patient.NPJ digital medicine · 2021Article
- One Health in allergology: A concept that connects humans, animals, plants, and the environment.Allergy · 2021Article
- Article
- Update of the S2k guideline on the management of IgE-mediated food allergies.Allergologie select · 2021Article
- Erroneous Belief that Digestive Stability Predicts Allergenicity May Lead to Greater Risk for Novel Food Proteins.Frontiers in bioengineering and biotechnology · 2021Article
- Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice.The Journal of allergy and clinical immunology · 2020Article
- Reply to "Acid inhibitors and allergy: comorbidity, causation and confusion".Nature communications · 2020Article
- Acid inhibitors and allergy: comorbidity, causation and confusion.Nature communications · 2020Article
- Increased risk of death associated with the use of proton-pump inhibitors in patients with dementia and controls - a pharmacoepidemiological claims data analysis.European journal of neurology · 2020Article
- Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies.International journal of molecular sciences · 2020Review
- Proton Pump Inhibitors in Children: the Good, the Bad, and the Ugly.Current allergy and asthma reports · 2020Review
- Dysbiosis of the gut and lung microbiome has a role in asthma.Seminars in immunopathology · 2020Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric acid suppression promotes allergy in mechanistic animal experiments and observational human studies, but whether gastric acid inhibitors increase allergy incidence at a population level remains uncharacterized. Here we aim to assess the use of anti-allergic medication following prescription of gastric acid inhibitors. We analyze data from health insurance records covering 97% of Austrian population between 2009 and 2013 on prescriptions of gastric acid inhibitors, anti-allergic drugs, or other commonly prescribed (lipid-modifying and antihypertensive) drugs as controls. Here we show that rate ratios for anti-allergic following gastric acid-inhibiting drug prescriptions are 1.96 (95%CI:1.95-1.97) and 3.07 (95%-CI:2.89-3.27) in an overall and regional Austrian dataset. These findings are more prominent in women and occur for all assessed gastric acid-inhibiting substances. Rate ratios increase from 1.47 (95%CI:1.45-1.49) in subjects <20 years, to 5.20 (95%-CI:5.15-5.25) in > 60 year olds. We report an epidemiologic relationship between gastric acid-suppression and development of allergic symptoms.
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