ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Temporal Coding of Reward Value in Monkey Ventral Striatal Tonically Active Neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Chemogenetic Disruption of Monkey Perirhinal Neurons Projecting to the Rostromedial Caudate Impairs Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Attractor dynamics reflect decision confidence in macaque prefrontal cortex.Nature neuroscience · 2023Article
- Unilateral caudate inactivation increases motor impulsivity in rhesus monkeys.Current research in neurobiology · 2023Article
- Single caudate neurons encode temporally discounted value for formulating motivation for action.eLife · 2021Article
- Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.Nature communications · 2020Article
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Authors and funding
6 authors.
Funding
Abstract
The rostromedioventral striatum is critical for behavior dependent on evaluating rewards. We asked what contribution tonically active neurons (TANs), the putative striatal cholinergic interneurons, make in coding reward value in this part of the striatum. Two female monkeys were given the option to accept or reject an offered reward in each trial, the value of which was signaled by a visual cue. Forty-five percent of the TANs use temporally modulated activity to encode information about discounted value. These responses were significantly better represented using principal component analysis than by just counting spikes. The temporal coding is straightforward: the spikes are distributed according to a sinusoidal envelope of activity that changes gain, ranging from positive to negative according to discounted value. Our results show that the information about the relative value of an offered reward is temporally encoded in neural spike trains of TANs. This temporal coding may allow well tuned, coordinated behavior to emerge.
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Registered trials
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