ArticleProceedings of the National Academy of Sciences of the United States of America2019
Effects of the peer metagenomic environment on smoking behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- [Association analysis between genetic nurturing effects ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Neurobehavioural genes exert indirect genetic effects on blood lipid profiles through behavioural traits.Communications biology · 2026Article
- Analysis of Sex-Specific Gene-by-Cohort and Genetic Correlation-by-Cohort Interaction in Educational and Reproductive Outcomes Using the UK Biobank Data.Journal of health and social behavior · 2024Article
- Peer Social Genetic Effects and the Etiology of Substance Use Disorders, Major Depression, and Anxiety Disorder in a Swedish National Sample.The American journal of psychiatry · 2024Article
- Heterogeneous peer effects of college roommates on academic performance.Nature communications · 2024Article
- Partners in Health: Investigating Social Genetic Effects Among Married and Cohabiting Couples.Behavior genetics · 2023Article
- Wrestling with Social and Behavioral Genomics: Risks, Potential Benefits, and Ethical Responsibility.The Hastings Center report · 2023Article
- Gene-by-peer-environment interaction effects on cigarette, alcohol, and marijuana use among US high school students of European Ancestry.Social science & medicine (1982) · 2022Article
- Indirect Genetic Effects: A Cross-disciplinary Perspective on Empirical Studies.The Journal of heredity · 2022Article
- Innovative methods to analyse the impact of gender norms on adolescent health using global health survey data.Social science & medicine (1982) · 2022Article
- Evaluating the Continued Integration of Genetics into Medical Sociology.Journal of health and social behavior · 2021Article
- Dissecting indirect genetic effects from peers in laboratory mice.Genome biology · 2021Article
- "Reports of My Death Were Greatly Exaggerated": Behavior Genetics in the Postgenomic Era.Annual review of psychology · 2021Review
- Transpersonal Genetic Effects Among Older U.S. Couples: A Longitudinal Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Disentangling Social-Genetic From Rearing-Environment Effects for Alcohol Use Disorder Using Swedish National Data.Psychological science · 2020Observational
- Separating Measured Genetic and Environmental Effects: Evidence Linking Parental Genotype and Adopted Child Outcomes.Behavior genetics · 2020Article
- Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Recent scholarship suggests that the genomes of those around us affect our own phenotypes. Much of the empirical evidence for such "metagenomic" effects comes from animal studies, where the socio-genetic environment can be easily manipulated. Among humans, it is more difficult to identify such effects given the nonrandom distribution of genes and environments. Here we leverage the as-if-random distribution of grade-mates' genomes conditional on school-level variation in a nationally representative sample. Specifically, we evaluate whether one's peers' genetic propensity to smoke affects one's own smoking behavior net of one's own genotype. Results show that peer genetic propensity to smoke has a substantial effect on an individual's smoking outcome. This is true not only when the peer group includes direct friends, and therefore where the individual plays an active role in shaping the metagenomic context but also when the peer group includes all grade-mates and thus in cases where the individual does not select the metagenomic environment. We explore these effects further and show that a small minority with high genetic risk to smoke ('bad apples') can greatly affect the smoking behavior of an entire grade. The methodology used in this paper offers a potential solution to many of the challenges inherent in estimating peer effects in nonexperimental settings and can be utilized to study a wide range of outcomes with a genetic basis. On a policy level, our results suggest that efforts to reduce adolescent smoking should take into account metagenomic effects, especially bad apples, within social networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.