Evidence map›Paper›PMID 31363026›Full record

ArticlemBio2019

Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression.

Bin Zhou, Fei Qi, Fangyi Wu, Hongbo Nie, Yifan Song, Lu Shao, Jingxuan Han, Zhen Wu, Hexige Saiyin, Gang Wei and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 68 citations in OpenAlex.

  1. Vitamin DApplied microbiology and biotechnology · 2026
    Review
  2. Article
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  9. Article
  10. Functional Bidirectionality of ERV-Derived Long Non-Coding RNAs in Humans.International journal of molecular sciences · 2024
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Human endogenous retroviruses and exogenous viral infections.Frontiers in cellular and infection microbiology · 2024
    Review
  16. Review
  17. Article
  18. Review
  19. Human Endogenous Retroviruses in Diseases.Sub-cellular biochemistry · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Bin ZhouState Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Fei QiMinistry of Education Key Laboratory of Contemporary Anthropology, Human Phenome Institute, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Fangyi WuMinistry of Education Key Laboratory of Contemporary Anthropology, Human Phenome Institute, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Hongbo NieState Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Yifan SongState Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Lu ShaoShanghai Vocational College of Agriculture and Forestry, Shanghai, People's Republic of China.
Jingxuan HanMinistry of Education Key Laboratory of Contemporary Anthropology, Human Phenome Institute, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Zhen WuState Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Hexige SaiyinState Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Gang WeiState Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Penghua WangDepartment of Immunology, School of Medicine, UConn Health, Farmington, Connecticut, USA.
Ting NiState Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University, Shanghai, People's Republic of China tingni@fudan.edu.cn fengqian@fudan.edu.cn.
Feng QianMinistry of Education Key Laboratory of Contemporary Anthropology, Human Phenome Institute, School of Life Sciences, Fudan University, Shanghai, People's Republic of China tingni@fudan.edu.cn fengqian@fudan.edu.cn.
Fudan University · CNHuashan Hospital · CNState Key Laboratory of Genetic EngineeringUConn Health · US

Funding

The role of UBXNs in antiviral immunityR01AI132526 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WANG, PENGHUA · 2018 to 2022
$2.1M
NIAID NIH HHS R01 AI132526
6 · The paper itself

Abstract

Endogenous retroviruses (ERVs) are transposable elements that cause host genome instability and usually play deleterious roles in disease such as tumorigenesis. Recent advances also suggest that this "enemy within" may encode a viral mimic to induce antiviral immune responses through viral sensors. Here, through whole-genome transcriptome analysis with RNA sequencing (RNA-Seq), we discovered that a full-length ERV-derived long noncoding RNA (lncRNA), designated lnc-EPAV (ERV-derived lncRNA positively regulates antiviral responses), was a positive regulator of NF-κB signaling. lnc-EPAV expression was rapidly upregulated by viral RNA mimics or RNA viruses to facilitate the expression of RELA, an NF-κB subunit that plays a crucial role in antiviral responses. Transcriptome analysis of lnc-EPAV-silenced macrophages showed that lnc-EPAV was critical for RELA target gene expression and innate immune responses. Consistently, lnc-EPAV-deficient mice exhibited reduced expression of type I interferons (IFNs) and, consequently, increased viral loads and mortality following lethal RNA virus infection. Mechanistically, lnc-EPAV promoted expression of RELA by competitively binding to and displacing SFPQ, a transcriptional repressor of

Indexed as

AnimalsBlotting, NorthernChlorocebus aethiopsEnzyme-Linked Immunosorbent AssayHEK293 CellsHumansImmunity, InnateImmunoblottingImmunoprecipitationInterferon Type IMiceMice, KnockoutMicroscopy, FluorescenceRNA, Long NoncodingTranscription Factor RelAVero CellsInterferon Type IRNA, Long NoncodingTranscription Factor RelAantiviral immune responsesendogenous retrovirusesgene regulationlncRNANF-κB

Identifiers

PMID31363026
PMCPMC6667616
OpenAlexW2964484898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.