Evidence map›Paper›PMID 31363023›Full record

ArticlemBio2019

Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy.

Michelle M Bellerose, Seung-Hun Baek, Chuan-Chin Huang, Caitlin E Moss, Eun-Ik Koh, Megan K Proulx, Clare M Smith, Richard E Baker, Jong Seok Lee, Seokyong Eum and 4 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 118 citations in OpenAlex.

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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Michelle M Bellerose *Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID 0000-0003-0232-9953
Seung-Hun Baek *Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea.
Chuan-Chin HuangDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Caitlin E MossDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Eun-Ik KohDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Megan K ProulxDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-9524-8302
Clare M SmithDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID 0000-0003-2601-0955
Richard E BakerDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jong Seok LeeInternational Tuberculosis Research Center, Changwon, South Korea.
Seokyong EumInternational Tuberculosis Research Center, Changwon, South Korea.
Sung Jae ShinDepartment of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea.
Sang-Nae ChoInternational Tuberculosis Research Center, Changwon, South Korea.
Megan MurrayDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Christopher M SassettiDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA Christopher.Sassetti@umassmed.edu.
University of Massachusetts Chan Medical School · USInternational Tuberculosis Research Center · KRHarvard University · USYonsei University · KR

Funding

Sequencing CoreU19AI109755 · NIAID · HARVARD MEDICAL SCHOOL · PI CHANDLER, DARRELL P, CULHANE, AEDIN C · 2014 to 2018
$29.1M
TRAINING IN IMMUNOLOGY (COMPETITIVE RENEWAL OF AI07439)T32AI007349 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J. · 1989 to 2024
$4.5M
NIAID NIH HHS T32 AI007349NIAID NIH HHS U19 AI109755
6 · The paper itself

Abstract

Despite the administration of multiple drugs that are highly effective

Indexed as

Antitubercular AgentsDrug Resistance, Multiple, BacterialGlycerol KinaseMicrobial Sensitivity TestsMycobacterium tuberculosisAntitubercular AgentsGlycerol Kinaseantibiotic resistancegeneticsMycobacterium tuberculosis

Identifiers

PMID31363023
PMCPMC6667613
OpenAlexW2965833449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.