Evidence map›Paper›PMID 31362985›Full record

ArticleThe Journal of biological chemistry2019

An engineered mutant of a host phospholipid synthesis gene inhibits viral replication without compromising host fitness.

Guijuan He, Zhenlu Zhang, Preethi Sathanantham, Xin Zhang, Zujian Wu, Lianhui Xie, Xiaofeng Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Guijuan HeFujian Province Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.
Zhenlu ZhangFujian Province Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.
Preethi SathananthamSchool of Plant and Environmental Sciences, Virginia Tech, Blacksburg, Virginia 24061.
Xin ZhangSchool of Plant and Environmental Sciences, Virginia Tech, Blacksburg, Virginia 24061.
Zujian WuFujian Province Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.
Lianhui XieFujian Province Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China fjxlh@126.com.
Xiaofeng WangSchool of Plant and Environmental Sciences, Virginia Tech, Blacksburg, Virginia 24061 reachxw@vt.edu.ORCID 0000-0002-3850-3274
Fujian Agriculture and Forestry University · CNVirginia Tech · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral infections universally rely on numerous hijacked host factors to be successful. It is therefore possible to control viral infections by manipulating host factors that are critical for viral replication. Given that host genes may play essential roles in certain cellular processes, any successful manipulations for virus control should cause no or mild effects on host fitness. We previously showed that a group of positive-strand RNA viruses enrich phosphatidylcholine (PC) at the sites of viral replication. Specifically, brome mosaic virus (BMV) replication protein 1a interacts with and recruits a PC synthesis enzyme, phosphatidylethanolamine methyltransferase, Cho2p, to the viral replication sites that are assembled on the perinuclear endoplasmic reticulum (ER) membrane. Deletion of the

Indexed as

BromovirusEndoplasmic ReticulumGenetic EngineeringPhosphatidylcholinesPhosphatidylethanolamine N-MethyltransferasePhospholipidsRNA, ViralSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsViral ProteinsVirus ReplicationCHO2 protein, S cerevisiaePhosphatidylcholinesPhosphatidylethanolamine N-MethyltransferasePhospholipidsRNA, ViralSaccharomyces cerevisiae ProteinsViral Proteinsmetabolic engineeringphosphatidylcholinephosphatidylethanolamine methyltransferaseplus-stranded RNA virusprotein targetingviral replicationviral replication complexvirus control

Identifiers

PMID31362985
PMCPMC6755795
OpenAlexW2964700770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.