Evidence map›Paper›PMID 31362984›Full record

ArticleThe Journal of biological chemistry2019

ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells.

Eun Hee Han, Puja Singh, In-Kyu Lee, Raul Urrutia, Young-In Chi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Eun Hee HanSection of Structural Biology, Hormel Institute, University of Minnesota, Austin, Minnesota 55912.
Puja SinghSection of Structural Biology, Hormel Institute, University of Minnesota, Austin, Minnesota 55912.
In-Kyu LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Republic of Korea.
Raul UrrutiaGenomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226.
Young-In ChiSection of Structural Biology, Hormel Institute, University of Minnesota, Austin, Minnesota 55912 ychi@mcw.edu.ORCID 0000-0001-9220-9511
University of Minnesota · USKyungpook National University Hospital · KRMedical College of Wisconsin · US

Funding

ZINC FINGER GENES AND PANCREATIC CELL GROWTHR01DK052913 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI LOMBERK, GWEN, URRUTIA, RAUL A. · 1998 to 2023
$7.0M
NIDDK NIH HHS R01 DK052913
6 · The paper itself

Abstract

HNF4α (hepatocyte nuclear factor 4α) is one of the master regulators of pancreatic β-cell development and function, and mutations in the

Indexed as

Adaptor Proteins, Signal TransducingCarrier ProteinsDiabetes Mellitus, Type 2DNA-Binding ProteinsGene Expression RegulationHeLa CellsHepatocyte Nuclear Factor 4HumansInsulinInsulin-Secreting CellsInsulin SecretionPromoter Regions, GeneticProtein BindingRNA-Binding ProteinsTranscription FactorsAdaptor Proteins, Signal TransducingCarrier ProteinsDNA-Binding ProteinsHepatocyte Nuclear Factor 4HNF4A protein, humanInsulinPA2G4 protein, humanRNA-Binding ProteinsTranscription FactorscorepressordiabetesEBP1gene regulationHNF4alphainsulin secretionmetabolic regulationnuclear receptorpancreatic beta-cellprotein complexprotein–protein interaction

Identifiers

PMID31362984
PMCPMC6755798
OpenAlexW2965737814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.