ArticleeNeuro
Heartbeat Induces a Cortical Theta-Synchronized Network in the Resting State.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heartbeat-Evoked Responses in M/EEG: A Systematic Review of Methods With Suggestions for Analysis and Reporting.Psychophysiology · 2026Pooled it
- Review
- Characterizing the Heartbeat-Evoked Potential: A Two-Component Model of Cardiac Signal Processing?Psychophysiology · 2025Article
- Predicting attentional focus: Heartbeat-evoked responses and brain dynamics during interoceptive and exteroceptive processing.PNAS nexus · 2024Article
- Brain-heart interaction disruption in major depressive disorder: disturbed rhythm modulation of the cardiac cycle on brain transient theta bursts.European archives of psychiatry and clinical neuroscience · 2024Article
- An autonomic mode of brain activity.Progress in neurobiology · 2023Article
- Systemic physiology augmented functional near-infrared spectroscopy: a powerful approach to study the embodied human brain.Neurophotonics · 2022Article
- Cardiac sympathetic-vagal activity initiates a functional brain-body response to emotional arousal.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot study.Frontiers in neurology · 2022Article
- The Slowest Shared Resonance: A Review of Electromagnetic Field Oscillations Between Central and Peripheral Nervous Systems.Frontiers in human neuroscience · 2021Review
- When the inner clock fades: Interoceptive decline and consolidation of phase resetting in cortical rhythms by cardiac events underlie healthy lifespan aging.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
2 authors.
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Abstract
In the resting state, heartbeats evoke cortical responses called heartbeat-evoked responses (HERs), which reflect cortical cardiac interoceptive processing. While previous studies have reported that the heartbeat evokes cortical responses at a regional level, whether the heartbeat induces synchronization between regions to form a network structure remains unknown. Using resting-state MEG data from 85 human subjects of both genders, we first showed that heartbeat increases the phase synchronization between cortical regions in the theta frequency but not in other frequency bands. This increase in synchronization between cortical regions formed a network structure called the heartbeat-induced network (HIN), which did not reflect artificial phase synchronization. In the HIN, the left inferior temporal gyrus and parahippocampal gyrus played a central role as hubs. Furthermore, the HIN was modularized, containing five subnetworks called modules. In particular, module 1 played a central role in between-module interactions in the HIN. Furthermore, synchronization within module 1 had a positive association with the mood of an individual. In this study, we show the existence of the HIN and its network properties, advancing the current understanding of cortical heartbeat processing and its relationship with mood, which was previously confined to region level.
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