Evidence map›Paper›PMID 31362785›Full record

Trial reportArthritis research & therapy2019

Local ice cryotherapy decreases synovial interleukin 6, interleukin 1β, vascular endothelial growth factor, prostaglandin-E2, and nuclear factor kappa B p65 in human knee arthritis: a controlled study.

X Guillot, N Tordi, C Laheurte, L Pazart, C Prati, P Saas, D Wendling

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03850392 (Effects of Local Cryotherapy on Cytokine, VRGF, NFkB and PG-E2 Levels in Knee Arthritis), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03850392 nacompletednot on this map

Effects of Local Cryotherapy on Cytokine, VRGF, NFkB and PG-E2 Levels in Knee Arthritis

TypeinterventionalSponsorCentre Hospitalier Universitaire de BesanconRan2013 to 2017Enrolled47ConditionsArthritis Knee, Cryotherapy EffectArmscryotherapy (Thermogel - Artsana or Cryo+ - Cryonic)
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

X GuillotDepartment of Rheumatology, Felix Guyon University Hospital, Saint-Denis, Reunion, France. xavier.guillot@chu-reunion.fr.ORCID 0000-0002-1217-7351
N TordiPEPITE EA4267, FHU INCREASE, Bourgogne-Franche-Comté University, Besançon, France.
C LaheurteINSERM U1098, Biomonitoring Platform, EFS, Besançon University Hospital, Besançon, France.
L PazartCIC IT, INSERM Center CIT 808, Besançon University Hospital, Besançon, France.
C PratiPEPITE EA4267, FHU INCREASE, Bourgogne-Franche-Comté University, Besançon, France.
P SaasINSERM U1098, Biomonitoring Platform, EFS, Besançon University Hospital, Besançon, France.
D WendlingDepartment of Rheumatology, Besançon university hospital, Besançon, France.
Inserm · FRCentre Hospitalier Universitaire de Besançon · FRCentre Hospitalier Universitaire de La Réunion · FRUniversité Bourgogne Franche-Comté · FR

Funding

GIRCI Est II "Young scientist" grant - 2014 - 21324 euros
6 · The paper itself

Abstract

backgroundThe aim of this study was to assess the anti-inflammatory effects of local cryotherapy in human non-septic knee arthritis.

methodsIn the phase I of the study, patients were randomized to receive either ice (30 min; N = 16) or cold CO

resultsForty-seven patients were included (17 gouts, 11 calcium pyrophosphate deposition diseases, 13 rheumatoid arthritides, 6 spondyloarthritides). Local ice cryotherapy significantly reduced the IL-6, IL-1β, VEGF, NF-kB-p65, and PG-E2 synovial levels, especially in the microcrystal-induced arthritis subgroup, while only phosphorylated NF-kB-p65 significantly decreased in rheumatoid arthritis and spondyloarthritis patients. Cold CO

conclusionsThese results suggest that local ice cryotherapy reduces IL-6, IL-1β, and VEGF synovial protein levels, mainly in microcrystal-induced arthritis, and potentially through NF-kB and PG-E2-dependent mechanisms.

trial registrationClinicaltrials.gov, NCT03850392-registered February 20, 2019-retrospectively registered.

Indexed as

AdultAgedBiomarkersCryotherapyEnzyme-Linked Immunosorbent AssayFemaleHumansInterleukin-1betaInterleukin-6MaleMiddle AgedNF-kappa BOsteoarthritis, KneeSynovial FluidTreatment OutcomeVascular Endothelial Growth Factor ABiomarkersIL1B protein, humanInterleukin-1betaInterleukin-6NF-kappa BVascular Endothelial Growth Factor ACytokinesKnee arthritisLocal cryotherapyNF-kBPG-E2

Identifiers

PMID31362785
PMCPMC6668066
OpenAlexW2965362894

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.