ArticleCritical care (London, England)2019
Vitamin C administration in the critically ill: a summary of recent meta-analyses.
Article in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis.Intensive care medicine · 2022Pooled it
- Mortality in septic patients treated with vitamin C: a systematic meta-analysis.Critical care (London, England) · 2021Pooled it
- Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial.Critical care (London, England) · 2022Trial
- Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial.European journal of medical research · 2021Trial
- Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial.JAMA network open · 2021Trial
- The Role of Vitamins in Sepsis: A Narrative Review.Nutrients · 2025Review
- Article
- Intravenous vitamin C monotherapy in critically ill patients: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis.Annals of intensive care · 2023Review
- Article
- Implications of Vitamins in COVID-19 Prevention and Treatment through Immunomodulatory and Anti-Oxidative Mechanisms.Antioxidants (Basel, Switzerland) · 2021Review
- Any Role of High-Dose Vitamin C for Septic Shock in 2021?Seminars in respiratory and critical care medicine · 2021Article
- Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition.World journal of gastroenterology · 2021Review
- Novel corona virus (COVID-19); Global efforts and effective investigational medicines: A review.Journal of infection and public health · 2021Review
- Vitamins, supplements and COVID-19: a review of currently available evidence.Drugs in context · 2021Review
- Dietary Supplements for COVID-19.Advances in experimental medicine and biology · 2021Review
- Current State of Evidence: Influence of Nutritional and Nutrigenetic Factors on Immunity in the COVID-19 Pandemic Framework.Nutrients · 2020Review
- Never a rose without a prick: pseudohyperglycemia when administering high-dose intravenous vitamin C.Critical care (London, England) · 2020Article
- Is the VITAMINS RCT indicating potential redundancy between corticosteroids and vitamin C?Critical care (London, England) · 2020Article
- Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review.Annals of intensive care · 2020Review
- Micronutrients in critically ill patients with severe acute kidney injury - a prospective study.Scientific reports · 2020Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.