Evidence map›Paper›PMID 31362771›Full record

ArticleJournal of orthopaedic surgery and research2019

CHRNA5/CHRNA3 gene cluster is a risk factor for lumbar disc herniation: a case-control study.

Xuejun Yang, Xiaodong Guo, Zhi Huang, Yifeng Da, Wenhua Xing, Feng Li, Manglai Li, Ke Sun, Haiyu Jia, Yong Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Incidence of and risk factors for lumbar disc herniation with radiculopathy in adults: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Pooled it
  2. Article
  3. Article
  4. Association betweenCell cycle (Georgetown, Tex.) · 2022
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Xuejun YangSpine (Thoracic and Vertebra) Department, the Second Affiliated Hospital of Inner Mongolia University, #1 Yingfang Road, Hohhot, 010050, Inner Mongolia, China.
Xiaodong GuoInner Mongolia People's Hospital, Hohhot, Inner Mongolia, China.
Zhi HuangSpine (Thoracic and Vertebra) Department, the Second Affiliated Hospital of Inner Mongolia University, #1 Yingfang Road, Hohhot, 010050, Inner Mongolia, China.
Yifeng DaInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Wenhua XingSpine (Thoracic and Vertebra) Department, the Second Affiliated Hospital of Inner Mongolia University, #1 Yingfang Road, Hohhot, 010050, Inner Mongolia, China.
Feng LiSpine (Thoracic and Vertebra) Department, the Second Affiliated Hospital of Inner Mongolia University, #1 Yingfang Road, Hohhot, 010050, Inner Mongolia, China.
Manglai LiInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Ke SunInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Haiyu JiaThe Affiliated Hospital of Inner Mongolia Medical College, #1 North Tongdao Road, Hohhot, 010020, Inner Mongolia, China. nmjiahaiyu@qq.com.
Yong ZhuSpine (Thoracic and Vertebra) Department, the Second Affiliated Hospital of Inner Mongolia University, #1 Yingfang Road, Hohhot, 010050, Inner Mongolia, China. yongzhu113@163.com.ORCID http://orcid.org/0000-0003-0407-4261
Inner Mongolia University · CNInner Mongolia Medical University · CNInner Mongolia Medical College Hospital · CNInner Mongolia People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLumbar disc herniation, a type of chronic low back pain syndrome, is caused by the lumbar intervertebral disk degeneration. Genetic variation in the CHRNA5/CHRNA3 has shown strong associations with smoking-related diseases. This study's aim is to test whether single-nucleotide polymorphisms in the CHRNA5/CHRNA3 gene are associated with lumbar disc herniation risk.

methodsThe genotype frequency distributions of the polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism in 380 lumbar disc herniation patients (case group) and 400 healthy individuals (control group). Allelic, genotypic, and haplotype analyses were performed.

resultsWe found that the individuals with rs8040868 CT genotype had a 0.46-fold higher risk of lumbar disc herniation than those with rs8040868 TT genotype, in men group (OR = 0.46, 95% CI 0.25-0.84, p = 0.012). Also among women, rs8040868 CT + CC genotype still reduced the risk of lumbar disc herniation under the dominant model (OR = 0.50, 95% CI 0.28-0.89, p = 0.019). Haplotype analysis showed that compared with the CHRNA5 "TACAACCG" wild-type, the "TACACCCG" haplotype was found to be associated with a decreased risk of lumbar disc herniation (LDH) (OR = 0.79, 95% CI 0.63-1.00, p = 0.047), while, in the less than 50-year-old group, CHRNA5 "TACACCCG" increased the risk of LDH (OR = 1.46, 95% CI 1.01-2.13, p = 0.047).

conclusionsOur data suggest that gene variance in the CHRNA5/CHRNA3 is associated with risk of lumbar disc herniation in the case-control study.

Indexed as

Lumbar VertebraeAdultCase-Control StudiesFemaleGenetic Association StudiesHumansIntervertebral Disc DisplacementMaleMiddle AgedMultigene FamilyNerve Tissue ProteinsPolymorphism, Single NucleotideReceptors, NicotinicRisk FactorsCHRNA5 protein, humanNerve Tissue ProteinsReceptors, NicotinicCHRNA5/CHRNA3Lumbar disc herniationSingle-nucleotide polymorphismSusceptibility

Identifiers

PMID31362771
PMCPMC6668080
OpenAlexW2965047829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.