ReviewCritical care (London, England)2019
Limb ischemia in peripheral veno-arterial extracorporeal membrane oxygenation: a narrative review of incidence, prevention, monitoring, and treatment.
Review in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05830721 (Continuous Compartment Pressure Monitoring for Compartment Syndrome in Venoarterial-Extracorporeal Membrane Oxygenation Patients - A Preliminary Feasibility Study), which is not on this map. Cited by 87 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Continuous Compartment Pressure Monitoring for Compartment Syndrome in Venoarterial-Extracorporeal Membrane Oxygenation Patients - A Preliminary Feasibility Study
Who cites it
87 citing papers in PubMed, 3 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- Extracorporeal Membrane Oxygenation Cannulation by Intensivists: A Systematic Review and Meta-Analysis.Journal of intensive care medicine · 2026Pooled it
- Assessment of safety and effectiveness after percutaneous closure for decannulation of Veno-Arterial Extracorporeal Membrane Oxygenation: A systematic review and meta-analysis.The journal of vascular access · 2025Pooled it
- Neurological Complications of the Lower Extremities After Femoral Cannulated Extracorporeal Membrane Oxygenation: A Systematic Review.Journal of intensive care medicine · 2024Pooled it
- Population Pharmacokinetics of Intravenous Infusion of Hydromorphone in Critically Ill Patients Supported by Extracorporeal Membrane Oxygenation.Clinical and translational science · 2026Trial
- Nucleated red blood cells are a predictor of mortality in patients under extracorporeal membrane oxygenation.European journal of medical research · 2023Trial
- Mitigating limb ischemia in veno-arterial extracorporeal membrane oxygenation: A narrative review of evolving role of distal perfusion catheters.World journal of critical care medicine · 2026Review
- Risk Analysis of Waiting-List Mortality in Heart Transplantation: A Multicenter Study in Korea.Yonsei medical journal · 2026Article
- Wire-guided puncture technique for lower limb distal perfusion catheter insertion after mechanical circulatory support.Cardiovascular intervention and therapeutics · 2026Article
- Toward standardized guidelines for distal perfusion cannulae in V-A ECMO and ECPELLA: timing, sizing, monitoring, and management.The journal of extra-corporeal technology · 2026Article
- Novel Use of a Distal Perfusion Catheter With a Removable Side Port in Patients on VA-ECMO.JACC. Case reports · 2026Article
- Machine learning models for predicting limb ischemia during VA-ECMO: an analysis of the Chinese extracorporeal life support registry.Critical care (London, England) · 2026Article
- Extracorporeal Life Support in Severe Accidental Hypothermia: Mechanisms, Challenges and Clinical Horizons.Journal of clinical medicine · 2026Review
- Modifying a traditional femoral venoarterial extracorporeal membrane oxygenation cannulation strategy and circuit to improve distal limb hemodynamics.JTCVS open · 2026Article
- Retrograde perfusion of the dorsalis pedis artery versus traditional distal perfusion catheter use in venoarterial extracorporeal membrane oxygenation.JTCVS open · 2026Article
- Percutaneous Versus Surgical Cannulation for Veno-Arterial Extracorporeal Life Support: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Percutaneous Versus Surgical Cannulation for Femoro-Femoral Venoarterial Extracorporeal Membrane Oxygenation: A Retrospective Cohort Study on Cannulation-Related Complications.Artificial organs · 2026Article
- Venoarterial extracorporeal membrane oxygenation in adults with cardiogenic shock.Frontiers in cardiovascular medicine · 2026Review
- Review
- Current perspectives and updates on transfusion strategies in critically ill anemic patients.Frontiers in medicine · 2026Review
- Case Report: Improved axillary artery cannulation and extracorporeal membrane oxygenation bridging therapy for cardiogenic shock caused by Marfan syndrome combined with aortic dissection.Frontiers in cardiovascular medicine · 2026Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is an increasingly adopted life-saving mechanical circulatory support for a number of potentially reversible or treatable cardiac diseases. It is also started as a bridge-to-transplantation/ventricular assist device in the case of unrecoverable cardiac or cardio-respiratory illness. In recent years, principally for non-post-cardiotomy shock, peripheral cannulation using the femoral vessels has been the approach of choice because it does not need the chest opening, can be quickly established, can be applied percutaneously, and is less likely to cause bleeding and infections than central cannulation. Peripheral ECMO, however, is characterized by a higher rate of vascular complications. The mechanisms of such adverse events are often multifactorial, including suboptimal arterial perfusion and hemodynamic instability due to the underlying disease, peripheral vascular disease, and placement of cannulas that nearly occlude the vessel. The effect of femoral artery damage and/or significant reduced limb perfusion can be devastating because limb ischemia can lead to compartment syndrome, requiring fasciotomy and, occasionally, even limb amputation, thereby negatively impacting hospital stay, long-term functional outcomes, and survival. Data on this topic are highly fragmentary, and there are no clear-cut recommendations. Accordingly, the strategies adopted to cope with this complication vary a great deal, ranging from preventive placement of antegrade distal perfusion cannulas to rescue interventions and vascular surgery after the complication has manifested.This review aims to provide a comprehensive overview of limb ischemia during femoral cannulation for VA-ECMO in adults, focusing on incidence, tools for early diagnosis, risk factors, and preventive and treating strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.