ArticleMalaria journal2019
Modelling reactive case detection strategies for interrupting transmission of Plasmodium falciparum malaria.
Article in Malaria journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Testing and treatment for malaria elimination: a systematic review.Malaria journal · 2023Pooled it
- Complexities in Defining the Unit of Intervention for Reactive Community-Based Malaria Treatment in the Gambia.Frontiers in public health · 2021Trial
- Supporting evidence-based decisions about the geographic and demographic extensions of seasonal malaria chemoprevention in Benin: A modelling study.PLOS global public health · 2025Article
- Advancing malaria reactive case detection in a Zambia-like setting: A modeling study.PLOS global public health · 2025Article
- Profiling vivax malaria incidence, residual transmission, and risk factors using reactive case detection in low transmission settings of Ethiopia.Malaria journal · 2024Article
- Using Passive Surveillance to Maintain Elimination as a Public Health Problem for Neglected Tropical Diseases: A Model-Based Exploration.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Quantifying the impact of interventions against Plasmodium vivax: A model for country-specific use.Epidemics · 2024Article
- Modelling the impact of interventions on imported, introduced and indigenous malaria infections in Zanzibar, Tanzania.Nature communications · 2023Article
- 1-3-7 surveillance and response approach in malaria elimination: China's practice and global adaptions.Malaria journal · 2023Review
- The impact of reactive case detection on malaria transmission in Zanzibar in the presence of human mobility.Epidemics · 2022Article
- Sub-national tailoring of malaria interventions in Mainland Tanzania: simulation of the impact of strata-specific intervention combinations using modelling.Malaria journal · 2022Article
- Prediction of malaria using deep learning models: A case study on city clusters in the state of Amazonas, Brazil, from 2003 to 2018.Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- Model-informed target product profiles of long-acting-injectables for use as seasonal malaria prevention.PLOS global public health · 2022Article
- Emulator-based Bayesian optimization for efficient multi-objective calibration of an individual-based model of malaria.Nature communications · 2021Article
- Analysis of a two-strain malaria transmission model with spatial heterogeneity and vector-bias.Journal of mathematical biology · 2021Article
- Costing malaria interventions from pilots to elimination programmes.Malaria journal · 2020Article
- Resurgence of malaria infection after mass treatment: a simulation study.Malaria journal · 2019Article
- "Remarkable solutions to impossible problems": lessons for malaria from the eradication of smallpox.Malaria journal · 2019Review
Corrections and comments
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3 authors.
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Abstract
backgroundAs areas move closer to malaria elimination, a combination of limited resources and increasing heterogeneity in case distribution and transmission favour a shift to targeted reactive interventions. Reactive case detection (RCD), the following up of additional individuals surrounding an index case, has the potential to target transmission pockets and identify asymptomatic cases in them. Current RCD implementation strategies vary, and it is unclear which are most effective in achieving elimination.
methodsOpenMalaria, an established individual-based stochastic model, was used to simulate RCD in a Zambia-like setting. The capacity to follow up index cases, the search radius, the initial transmission and the case management coverage were varied. Suitable settings were identified and probabilities of elimination and time to elimination estimated. The value of routinely collected prevalence and incidence data for predicting the success of RCD was assessed.
resultsThe results indicate that RCD with the aim of transmission interruption is only appropriate in settings where initial transmission is very low (annual entomological inoculation rate (EIR) 1-2 or prevalence approx. < 7-19% depending on case management levels). Every index case needs to be followed up, up to a maximum case-incidence threshold which defines the suitability threshold of settings for elimination using RCD. Increasing the search radius around index cases is always beneficial.
conclusionsRCD is highly resource intensive, requiring testing and treating of 400-500 people every week for 5-10 years for a reasonable chance of elimination in a Zambia-like setting.
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