Evidence map›Paper›PMID 31362457›Full record

ArticleMolecules (Basel, Switzerland)2019

Novel Benzothiazole-based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment.

Laura Aitken, Ondrej Benek, Brogan E McKelvie, Rebecca E Hughes, Lukas Hroch, Monika Schmidt, Louise L Major, Lucie Vinklarova, Kamil Kuca, Terry K Smith and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

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  14. Sulfur-containing therapeutics in the treatment of Alzheimer's disease.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Laura AitkenUniversity of St. Andrews, School of Biology, Medical and Biological Sciences Building, North Haugh, St. Andrews KY16 9TF, UK. la49@st-andrews.ac.uk.
Ondrej BenekUniversity Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. ondrej.benek@uhk.cz.
Brogan E McKelvieUniversity of St. Andrews, School of Biology, Medical and Biological Sciences Building, North Haugh, St. Andrews KY16 9TF, UK.
Rebecca E HughesCancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.
Lukas HrochUniversity Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Monika SchmidtUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Louise L MajorBiomedical Science Research Complex, University of St. Andrews, North Haugh, St. Andrews KY16 9ST, UK.
Lucie VinklarovaUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Kamil KucaUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Terry K SmithBiomedical Science Research Complex, University of St. Andrews, North Haugh, St. Andrews KY16 9ST, UK.
Kamil MusilekUniversity Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Frank J Gunn-MooreUniversity of St. Andrews, School of Biology, Medical and Biological Sciences Building, North Haugh, St. Andrews KY16 9TF, UK.
University of St Andrews · GBUniversity Hospital Hradec Králové · CZUniversity of Hradec Králové · CZWestern General Hospital · GB

Funding

Alzheimer's Society 291Ministry of Education, Youth and Sports of Czech Republic CZ.02.1.01/0.0/0.0/18_069/0010054Rosetrees Trust A2216RS MacDonald Charitable Trust 40th Anniversary AwardUniversity of Hradec Kralove Faculty of Science, no. VT2019-2021, SV2115-2018WT-ISSF ISSF3 University of St Andrews
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

17-Hydroxysteroid DehydrogenasesAlzheimer DiseaseAmyloid beta-PeptidesBenzothiazolesCell LineDose-Response Relationship, DrugDrug DesignHumansMitochondriaMolecular StructureStructure-Activity RelationshipUrea17-Hydroxysteroid DehydrogenasesAmyloid beta-PeptidesBenzothiazolesUrea17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10), amyloid binding alcohol dehydrogenase (ABAD), benzothiazoleAlzheimer’s disease (AD), amyloid-beta peptide (Aβ), mitochondria

Identifiers

PMID31362457
PMCPMC6696238
OpenAlexW2964605424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.