ArticleLife (Basel, Switzerland)2019
Modelling Bacteria-Inspired Dynamics with Networks of Interacting Chemicals.
Article in Life (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Reconfigurable Droplet-Droplet Communication Mediated by Photochemical Marangoni Flows.Journal of the American Chemical Society · 2024Article
- Feedback and Communication in Active Hydrogel Spheres with pH Fronts: Facile Approaches to Grow Soft Hydrogel Structures.Angewandte Chemie (International ed. in English) · 2021Article
- Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness.Life (Basel, Switzerland) · 2021Article
- pH Feedback Lifecycles Programmed by Enzymatic Logic Gates Using Common Foods as Fuels.Angewandte Chemie (International ed. in English) · 2021Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One approach to understanding how life-like properties emerge involves building synthetic cellular systems that mimic certain dynamical features of living cells such as bacteria. Here, we developed a model of a reaction network in a cellular system inspired by the ability of bacteria to form a biofilm in response to increasing cell density. Our aim was to determine the role of chemical feedback in the dynamics. The feedback was applied through the enzymatic rate dependence on pH, as pH is an important parameter that controls the rates of processes in cells. We found that a switch in pH can be used to drive base-catalyzed gelation or precipitation of a substance in the external solution. A critical density of cells was required for gelation that was essentially independent of the pH-driven feedback. However, the cell pH reached a higher maximum as a result of the appearance of pH oscillations with feedback. Thus, we conclude that while feedback may not play a vital role in some density-dependent behavior in cellular systems, it nevertheless can be exploited to activate internally regulated cell processes at low cell densities.
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