ArticleCells2019
Naturally Occurring Nervonic Acid Ester Improves Myelin Synthesis by Human Oligodendrocytes.
Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
- The pan-genome provides insights into evolutionary dynamics and fatty acid metabolism in Aceraceae family.Genome biology · 2026Article
- A Synergistic Genetic Engineering Strategy Induced Nervonic Acid inInternational journal of molecular sciences · 2026Article
- Hormone-sensitive lipase drives pro-resolving macrophage polarization and enhances efferocytosis.Cell communication and signaling : CCS · 2026Article
- Article
- Nervonic Acid fromBiomaterials research · 2026Article
- Erythrocyte membrane nervonic acid in drug-naive first-episode psychosis and chronic medicated schizophrenia: Implication for impaired myelination and prognosis.World journal of psychiatry · 2025Article
- Senolytic effects of a modified Gingerenone A.npj aging · 2025Article
- Effect of extraction methods on the lipidomics profiles ofFood chemistry: X · 2025Article
- Using gut microbiota and non-targeted metabolomics techniques to study the effect of xylitol on alleviating DSS-induced inflammatory bowel disease in mice.BMC immunology · 2025Article
- Population variation in fatty acid composition and response to climatic factors in Malania oleifera Chun et S.K. Lee.BMC plant biology · 2025Article
- Nervonic acid in infant nutrition: a forward-looking approach to enhancing neurodevelopmental outcomes.Frontiers in nutrition · 2025Review
- Nutritional roles and therapeutic potentials of dietary sphingomyelin in brain diseases.Journal of clinical biochemistry and nutrition · 2024Article
- Lipase-Catalyzed Preparation and Optimization of Structured Phosphatidylcholine Containing Nervonic Acid.Molecules (Basel, Switzerland) · 2024Article
- Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System Regeneration.International journal of molecular sciences · 2024Review
- Cross-sectional analysis of healthy individuals across decades: Aging signatures across multiple physiological compartments.Aging cell · 2024Article
- Nervonic acid alleviates radiation-induced early phase lung inflammation by targeting macrophages activation in mice.Frontiers in immunology · 2024Article
- Nervonic acid as novel therapeutics initiates both neurogenesis and angiogenesis for comprehensive wound repair and healing.Frontiers in pharmacology · 2024Article
- Erucic acid utilization byFrontiers in microbiology · 2024Article
- High-level production of nervonic acid in the oleaginous yeast Yarrowia lipolytica by systematic metabolic engineering.Communications biology · 2023Article
- Germplasm resources of three wood plant species enriched with nervonic acid.Plant diversity · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dysfunction of oligodendrocytes (OLs) is regarded as one of the major causes of inefficient remyelination in multiple sclerosis, resulting gradually in disease progression. Oligodendrocytes are derived from oligodendrocyte progenitor cells (OPCs), which populate the adult central nervous system, but their physiological capability to myelin synthesis is limited. The low intake of essential lipids for sphingomyelin synthesis in the human diet may account for increased demyelination and the reduced efficiency of the remyelination process. In our study on lipid profiling in an experimental autoimmune encephalomyelitis brain, we revealed that during acute inflammation, nervonic acid synthesis is silenced, which is the effect of shifting the lipid metabolism pathway of common substrates into proinflammatory arachidonic acid production. In the experiments on the human model of maturating oligodendrocyte precursor cells (hOPCs) in vitro, we demonstrated that fish oil mixture (FOM) affected the function of hOPCs, resulting in the improved synthesis of myelin basic protein, myelin oligodendrocyte glycoprotein, and proteolipid protein, as well as sphingomyelin. Additionally, FOM reduces proinflammatory cytokines and chemokines, and enhances fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor (VEGF) synthesis by hOPCs was also demonstrated. Based on these observations, we propose that the intake of FOM rich in the nervonic acid ester may improve OL function, affecting OPC maturation and limiting inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.