Evidence map›Paper›PMID 31362041›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2019

Salubrinal enhances eIF2α phosphorylation and improves fertility in a mouse model of Classic Galactosemia.

B Balakrishnan, A Siddiqi, J Mella, A Lupo, E Li, J Hollien, J Johnson, K Lai

Open access · greenAbstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  11. Harnessing the Power of Purple Sweet Potato Color andInternational journal of molecular sciences · 2022
    Article
  12. Article
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  15. Article
  16. Review
  17. Current and Future Treatments for Classic Galactosemia.Journal of personalized medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

B BalakrishnanDivision of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, United States.
A SiddiqiDepartment of Pathology and Laboratory Medicine, University of Florida College of Medicine, United States.
J MellaSchool of Biological Sciences, University of Utah College of Science, United States.
A LupoDivision of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, United States.
E LiDivision of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, United States.
J HollienSchool of Biological Sciences, University of Utah College of Science, United States.
J JohnsonDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Colorado, United States. Electronic address: JOSHUA.2.JOHNSON@UCDENVER.EDU.
K LaiDivision of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, United States. Electronic address: kent.lai@hsc.utah.edu.
University of Utah · USColorado Center for Reproductive Medicine · USUniversity of Florida · US

Funding

Regulation of mRNA decay and metabolism during endoplasmic reticulum stressR35GM119540 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HOLLIEN, JULIE · 2016 to 2025
$3.1M
Toward Improved Therapy for Classic GalactosemiaR01HD074844 · NICHD · UNIVERSITY OF UTAH · PI LAI, KENT · 2012 to 2014
$904k
NICHD NIH HHS R01 HD074844NIGMS NIH HHS R35 GM119540
6 · The paper itself

Abstract

Loss of galactose-1 phosphate uridylyltransferase (GALT) activity in humans results in Classic Galactosemia, and the GalT-deficient (GalT

Indexed as

AnimalsCinnamatesDisease Models, AnimalEukaryotic Initiation Factor-2FemaleFertilityGalactosemiasInfertility, FemaleMiceOvaryPhosphorylationThioureaUnfolded Protein ResponseCinnamatesEukaryotic Initiation Factor-2salubrinalThioureaClassic GalactosemiaGalactosemic stressPerk branch of the unfolded protein response (UPR)Pi3K/Akt signalingSalubrinalSubfertility

Identifiers

PMID31362041
PMCPMC6751024
OpenAlexW2966468896

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.