Evidence map›Paper›PMID 31361835›Full record

ArticleAmerican journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists2019

Allergic reactions to small-molecule drugs: Will we move from reaction to prediction?

Mark F Bonfiglio, David M Weinstein

Abstract readComment
PubMed Publisher
In one paragraph

Article in American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mark F BonfiglioLloyd L Gregory School of Pharmacy, Palm Beach Atlantic University, Palm Beach Gardens, FL.
David M WeinsteinWolters Kluwer Health Clinical Effectiveness, Hudson, OH.
Palm Beach Atlantic University · USWolters Kluwer Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis primer provides background and an update on immune mechanisms which allow small-molecule drugs to trigger drug allergy. SUMMARY: For many years, understanding of drug allergy was limited. The hapten model of drug allergy applies only to a subset of drugs known to cause allergic reactions. More recently, the understanding of immune reactions has expanded to include pharmacologic interactions with the molecules involved in immune identity and surveillance. These insights are presented and discussed here.

conclusionGreater understanding of allergic reactions to drugs offers the promise to move from a position of reacting to immune reactions to a more proactive model. This may translate to new opportunities to characterize risk in drug development, confirm the nature of reactions in clinical settings, enhance the targeting of alerts, and ultimately to allow patient-specific prediction.

Indexed as

Drug HypersensitivityHumansdelayed hypersensitivitydrug allergydrug eruptionsdrug hypersensitivityhypersensitivityimmediate hypersensitivityStevens–Johnson syndrome

Identifiers

PMID31361835
OpenAlexW2935882109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.