ArticlePloS one2019
Calibration with or without phantom for fracture risk prediction in cancer patients with femoral bone metastases using CT-based finite element models.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 65 citations in OpenAlex.
- Phantomless calibration of glenoid trabecular bone density: improved accuracy using age-stratified reference tissue densities.JBMR plus · 2026Article
- Effects of contrast on opportunistic computed tomography vertebral bone mineral density analysis using internal calibration.JBMR plus · 2026Article
- Longitudinal Density and Volume Changes of Periacetabular Cancellous and Cortical Bone.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Can FEM-based preoperative planning for complex tibial plateau fractures improve surgical skills? A cadaver study.Journal of orthopaedic surgery and research · 2026Article
- A pipeline to morph finite element models of the lumbar spine for generation of customised spinal cages.Journal of orthopaedic surgery and research · 2025Article
- Feasibility of 100 kV Low-voltage Bone Mineral Density Measurement with Quantitative CT: Phantom and Clinical Research.Calcified tissue international · 2025Article
- The Influence of Cup Orientation on the Primary Fixation of a Hemispherical Cementless Acetabular Cup: A Cohort Based Finite Element Study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Assessing the Influence of Screw Orientation on Fracture Fixation of the Proximal Humerus Using Finite Element Informed Surrogate Modeling.International journal for numerical methods in biomedical engineering · 2025Article
- Estimating temporal bone-implant stresses in patients with bone-anchored lower limbs.Journal of biomechanics · 2025Article
- Reverse Shoulder Arthroplasty Baseplate Stability Is Affected by Bone Density and the Type and Amount of Augmentation.Bioengineering (Basel, Switzerland) · 2025Article
- Parametrized statistical appearance and shape modelling strategy to predict proximal and diaphyseal femoral fractures.Frontiers in bioengineering and biotechnology · 2025Article
- Multi-site phantomless bone mineral density from clinical quantitative computed tomography in males.JBMR plus · 2024Article
- Asynchronous calibration of a CT scanner for bone mineral density estimation: sources of error and correction.JBMR plus · 2024Article
- The Effect of Patient-Related Factors on the Primary Fixation of PEEK and Titanium Tibial Components: A Population-Based FE Study.Bioengineering (Basel, Switzerland) · 2024Article
- Phantomless calibration of CT scans for hip fracture risk prediction in silico: Comparison with phantom-based calibration.PloS one · 2024Article
- Evaluation of finite element modeling methods for predicting compression screw failure in a custom pelvic implant.Frontiers in bioengineering and biotechnology · 2024Article
- Quantifying Bone Strength Deficits in Young Adults Born Extremely Preterm or Extremely Low Birth Weight.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Nanocomposite orthopaedic bone cement combining long-acting dual antimicrobial drugs.Biomaterials advances · 2023Article
- Addressing Challenges of Opportunistic Computed Tomography Bone Mineral Density Analysis.Diagnostics (Basel, Switzerland) · 2023Review
- Opportunistic Screening Techniques for Analysis of CT Scans.Current osteoporosis reports · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to develop a new calibration method that enables calibration of Hounsfield units (HU) to bone mineral densities (BMD) without the use of a calibration phantom for fracture risk prediction of femurs with metastases using CT-based finite element (FE) models. Fifty-seven advanced cancer patients (67 femurs with bone metastases) were CT scanned atop a separate calibration phantom using a standardized protocol. Non-linear isotropic FE models were constructed based on the phantom calibration and on two phantomless calibration methods: the "air-fat-muscle" and "non-patient-specific" calibration. For air-fat-muscle calibration, peaks for air, fat and muscle tissue were extracted from a histogram of the HU in a standardized region of interest including the patient's right leg and surrounding air. These CT peaks were linearly fitted to reference "BMD" values of the corresponding tissues to obtain a calibration function. For non-patient-specific calibration, an average phantom calibration function was used for all patients. FE failure loads were compared between phantom and phantomless calibrations. There were no differences in failure loads between phantom and air-fat-muscle calibration (p = 0.8), whereas there was a significant difference between phantom and non-patient-specific calibration (p<0.001). Although this study was not designed to investigate this, in four patients who were scanned using an aberrant reconstruction kernel, the effect of the different kernel seemed to be smaller for the air-fat-muscle calibration compared to the non-patient-specific calibration. With the air-fat-muscle calibration, clinical implementation of the FE model as tool for fracture risk assessment will be easier from a practical and financial viewpoint, since FE models can be made using everyday clinical CT scans without the need of concurrent scanning of calibration phantoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.