SynthesisPloS one2019
Intensive follow-up strategies after radical surgery for nonmetastatic colorectal cancer: A systematic review and meta-analysis of randomized controlled trials.
Synthesis in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the effectiveness of patient-initiated follow-up after cancer.Cancer medicine · 2023Pooled it
- Personalized surveillance in colorectal cancer: Integrating circulating tumor DNA and artificial intelligence into post-treatment follow-up.World journal of gastroenterology · 2025Article
- Peritoneal reflection involvement as a prognostic factor in rectal cancer. Long-term oncological outcomes from a prospective study.International journal of colorectal disease · 2025Observational
- Diagnostic yield of follow-up in patients undergoing surgery for non-metastatic colorectal cancer.World journal of gastroenterology · 2025Article
- The association of cognitive coping style with patient preferences in a patient-led follow-up study among colorectal cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Intensive follow-upWorld journal of gastrointestinal oncology · 2023Article
- Follow-up surveillance among colorectal cancer survivors of different sexual orientations.Journal of cancer survivorship : research and practice · 2022Article
- Defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors.International journal of colorectal disease · 2021Article
- Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer.World journal of gastrointestinal surgery · 2021Article
- Impact of Surgical Resection on Metachronous Metastases of Colorectal Cancer According to Tumor Doubling Time.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntensive follow-up after surgery for colorectal cancers is common in clinical practice, but evidence of a survival benefit is limited.
objectiveTo conduct a systematic review and meta-analysis on the effects of follow-up strategies for nonmetastatic colorectal cancer. DATA SOURCES: We searched Medline, Embase, and CENTRAL databases through May 30, 2018. STUDY SELECTION: We included randomized clinical trials evaluating intensive follow-up versus less follow-up in patients with nonmetastatic colorectal cancer.
interventionsIntensive follow-up. MAIN OUTCOMES MEASURES: Overall survival.
resultsThe analyses included 17 trials with a total of 8039 patients. Compared with less follow-up, intensive follow-up significantly improved overall survival in patients with nonmetastatic colorectal cancer after radical surgery (HR 0.85, 95% CI 0.74-0.97, P = 0.01; I2 = 30%; high quality). Subgroup analyses showed that differences between intensive-frequency and intensive-test follow-up (P = 0.04) and between short interval and long interval of follow-up (P = 0.02) in favor of the former one. LIMITATIONS: Clinical heterogeneity of interventions.
conclusionsFor patients with nonmetastatic colorectal cancer after curative resection, intensive follow-up strategy was associated with an improvement in overall survival compared with less follow-up strategy. Intensive-frequency follow-up strategy was associated with a greater reduction in mortality compared with intensive-test follow-up strategy.
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