Evidence map›Paper›PMID 31361623›Full record

ArticleAmerican journal of physical medicine & rehabilitation2020

A Model-Based Cost-Effectiveness Analysis of an Exercise Program for Lung Cancer Survivors After Curative-Intent Treatment.

Duc Ha, Jacqueline Kerr, Andrew L Ries, Mark M Fuster, Scott M Lippman, James D Murphy

Registry-linked trialAbstract read
In one paragraph

Article in American journal of physical medicine & rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05179408 (Telerehabilitation for Veteran Lung Cancer Survivors Following Curative Intent Therapy), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05179408 narecruitingnot on this mapstarted 2026, after this paper: background citation

Telerehabilitation for Veteran Lung Cancer Survivors Following Curative Intent Therapy

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2026 to 2027Enrolled40ConditionsLung Cancer, Cancer SurvivorsArmsTargeted-telerehabilitation, Waitlist
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Survivorship Challenges and Supportive Care in Lung Cancer.Seminars in respiratory and critical care medicine · 2025
    Review
  6. Article
  7. Cost-utility analysis of a supervised exercise intervention for women with early-stage endometrial cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Duc HaFrom the Institute for Health Research, Kaiser Permanente Colorado, Aurora, Colorado (DH); Division of Behavioral Medicine, Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, California (JK); Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California (DH, ALR, MMF); Section of Pulmonary and Critical Care Medicine, VA San Diego Healthcare System, San Diego, California (MMF); Moores Cancer Center, University of California San Diego, La Jolla, California (SML); and Gastrointestinal and Palliative Radiation Oncology, Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California (JDM).
Jacqueline Kerr
Andrew L Ries
Mark M Fuster
Scott M Lippman
James D Murphy

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
Assessment of Upper Airway Mechanics Using Newer Electromyographic TechniquesK24HL132105 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2016 to 2020
$611k
Glycocalyx Targeting and Augmenting Cellular Immunity in Lung CancerI01BX003688 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI FUSTER, MARK M · 2018 to 2025
–
BLRD VA I01 BX003688EPA EP-D-17-020NCATS NIH HHS UL1 TR001442NCI NIH HHS L30 CA208950NCI NIH HHS P30 CA023100NHLBI NIH HHS K24 HL132105NHLBI NIH HHS R01 HL085188NHLBI NIH HHS T32 HL134632
6 · The paper itself

Abstract

objectiveThe cost-effectiveness of exercise interventions in lung cancer survivors is unknown. We performed a model-based cost-effectiveness analysis of an exercise intervention in lung cancer survivors.

designWe used Markov modeling to simulate the impact of the Lifestyle Interventions and Independence for Elders exercise intervention compared with usual care for stage I-IIIA lung cancer survivors after curative-intent treatment. We calculated and considered incremental cost-effectiveness ratios of less than US $100,000/quality-adjusted life-year as cost-effective and assessed model uncertainty using sensitivity analyses.

resultsThe base-case model showed that the Lifestyle Interventions and Independence for Elders exercise program would increase overall cost by US $4740 and effectiveness by 0.06 quality-adjusted life-years compared with usual care and have an incremental cost-effectiveness ratio of US $79,504/quality-adjusted life-year. The model was most sensitive to the cost of the exercise program, probability of increasing exercise, and utility benefit related to exercise. At a willingness-to-pay threshold of US $100,000/quality-adjusted life-year, Lifestyle Interventions and Independence for Elders had a 71% probability of being cost-effective compared with 27% for usual care. When we included opportunity costs, Lifestyle Interventions and Independence for Elders had an incremental cost-effectiveness ratio of US $179,774/quality-adjusted life-year, exceeding the cost-effectiveness threshold.

conclusionsA simulation of the Lifestyle Interventions and Independence for Elders exercise intervention in lung cancer survivors demonstrates cost-effectiveness from an organization but not societal perspective. A similar exercise program for lung cancer survivors may be cost-effective.

Indexed as

Cancer SurvivorsCost-Benefit AnalysisAgedExercise TestExercise TherapyFemaleGeriatric AssessmentHumansLife StyleLung NeoplasmsMaleMarkov ChainsQuality-Adjusted Life YearsQuality of Life

Identifiers

PMID31361623
PMCPMC6982544

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.