Evidence map›Paper›PMID 31361464›Full record

ArticleACS synthetic biology2019

Spatiotemporal Dynamics of Synthetic Microbial Consortia in Microfluidic Devices.

Razan N Alnahhas, James J Winkle, Andrew J Hirning, Bhargav Karamched, William Ott, Krešimir Josić, Matthew R Bennett

Abstract read
In one paragraph

Article in ACS synthetic biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Dissecting the physics of bacterial biofilms with agent-based simulations.Current opinion in solid state & materials science · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Signaling in microbial communities with open boundaries.bioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Frequency dependent growth of bacteria in living materials.Frontiers in bioengineering and biotechnology · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Razan N AlnahhasDepartment of BioSciences , Rice University , Houston , Texas 77005 , United States.
James J WinkleDepartment of BioSciences , Rice University , Houston , Texas 77005 , United States.
Andrew J HirningDepartment of BioSciences , Rice University , Houston , Texas 77005 , United States.ORCID 0000-0001-5127-9193
Bhargav KaramchedDepartment of Mathematics , University of Houston , Houston , Texas 77004 , United States.
William OttDepartment of Mathematics , University of Houston , Houston , Texas 77004 , United States.
Krešimir JosićDepartment of BioSciences , Rice University , Houston , Texas 77005 , United States.
Matthew R BennettDepartment of BioSciences , Rice University , Houston , Texas 77005 , United States.ORCID 0000-0002-4975-8854

Funding

Expanding the utility of transcriptional bacterial computingR01GM117138 · NIGMS · RICE UNIVERSITY · PI BENNETT, MATTHEW R., JOSIC, KRESIMIR · 2016 to 2019
$2.0M
Experimental and mathematical analysis of delay in transcripitional signalingR01GM104974 · NIGMS · RICE UNIVERSITY · PI BENNETT, MATTHEW R. · 2012 to 2016
$1.4M
NIGMS NIH HHS R01 GM104974NIGMS NIH HHS R01 GM117138
6 · The paper itself

Abstract

Synthetic microbial consortia consist of two or more engineered strains that grow together and share the same resources. When intercellular signaling pathways are included in the engineered strains, close proximity of the microbes can generate complex dynamic behaviors that are difficult to obtain using a single strain. However, when a consortium is not cultured in a well-mixed environment the constituent strains passively compete for space as they grow and divide, complicating cell-cell signaling. Here, we explore the temporal dynamics of the spatial distribution of consortia cocultured in microfluidic devices. To do this, we grew two different strains of

Indexed as

Escherichia coliLab-On-A-Chip DevicesLuminescent ProteinsMicrobial ConsortiaMicrobial InteractionsMicrofluidicsQuorum SensingLuminescent Proteinsmicrobial consortiamicrofluidicsspatiotemporal patterning

Identifiers

PMID31361464
PMCPMC6754295

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.