ArticleHuman brain mapping2019
Disrupted brain functional networks in drug-naïve children with attention deficit hyperactivity disorder assessed using graph theory analysis.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of high-intensity interval training effects on cognitive function in older adults and cognitively impaired patients.Frontiers in physiology · 2025Pooled it
- Different Changes in Brain Functional Networks Following 12-Week Psychostimulant Treatment in Attention-Deficit/Hyperactivity Disorder Youth With and Without Familial Risk for Bipolar I Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Trial
- Emotion-Related Network Reorganization Following Fish Oil Supplementation in Depressed Bipolar Offspring: An fMRI Graph-Based Connectome Analysis.Journal of affective disorders · 2021Trial
- Learning image derived PDE-phenotypes from fMRI data.Brain informatics · 2025Article
- Reconfiguration of Functional Brain Network Organization and Dynamics With Changing Cognitive Demands in Children With Attention-Deficit/Hyperactivity Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Disrupted topological organization of brain connectome in patients with chronic low back related leg pain and clinical correlations.Scientific reports · 2025Article
- Disrupted small-world architecture and altered default mode network topology of brain functional network in college students with subclinical depression.BMC psychiatry · 2025Article
- Different brain functional network abnormalities between attention-deficit/hyperactivity disorder youth with and without familial risk for bipolar disorder.European child & adolescent psychiatry · 2024Article
- Multivariate Assessment of Inhibitory Control in Youth: Links With Psychopathology and Brain Function.Psychological science · 2024Article
- Impact of prenatal marijuana exposure on adolescent brain structural and functional connectivity and behavioural outcomes.Brain communications · 2024Article
- Evaluation of individual-based morphological brain network alterations in children with attention-deficit/hyperactivity disorder: a multi-method investigation.European child & adolescent psychiatry · 2023Article
- Functional and structural brain network development in children with attention deficit hyperactivity disorder.Human brain mapping · 2023Article
- Altered brain network topology in children with auditory processing disorder: A resting-state multi-echo fMRI study.NeuroImage. Clinical · 2022Article
- Classification of drug-naive children with attention-deficit/hyperactivity disorder from typical development controls using resting-state fMRI and graph theoretical approach.Frontiers in human neuroscience · 2022Article
- Resting-State fMRI Whole Brain Network Function Plasticity Analysis in Attention Deficit Hyperactivity Disorder.Neural plasticity · 2022Article
- Altered topological organization of resting-state functional networks in children with infantile spasms.Frontiers in neuroscience · 2022Article
- Disruption of human brain connectivity networks in patients with cervical spondylotic myelopathy.Quantitative imaging in medicine and surgery · 2021Article
- Cholinergic neuromodulation of inhibitory interneurons facilitates functional integration in whole-brain models.PLoS computational biology · 2021Article
- Shared and Distinct Topologically Structural Connectivity Patterns in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder.Frontiers in neuroscience · 2021Article
- Brain structural connectome in relation to PRRT2 mutations in paroxysmal kinesigenic dyskinesia.Human brain mapping · 2020Article
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Authors and funding
14 authors.
Funding
Abstract
Neuroimaging studies have revealed functional brain network abnormalities in attention deficit hyperactivity disorder (ADHD), but the results have been inconsistent, potentially related to confounding medication effects. Furthermore, specific topological alterations in functional networks and their role in behavioral inhibition dysfunction remain to be established. Resting-state functional magnetic resonance imaging was performed on 51 drug-naïve children with ADHD and 55 age-matched healthy controls. Brain functional networks were constructed by thresholding the partial correlation matrices of 90 brain regions, and graph theory was used to analyze network topological properties. The Stroop test was used to assess cognitive inhibitory abilities. Nonparametric permutation tests were used to compare the topological architectures in the two groups. Compared with healthy subjects, brain networks in ADHD patients demonstrated altered topological characteristics, including lower global (FDR q = 0.01) and local efficiency (p = 0.032, uncorrected) and a longer path length (FDR q = 0.01). Lower nodal efficiencies were found in the left inferior frontal gyrus and anterior cingulate cortex in the ADHD group (FDR both q < 0.05). Altered global and nodal topological efficiencies were associated with the severity of inhibitory cognitive control deficits and hyperactivity symptoms in ADHD (p <0 .05). Alterations in network topologies in drug-naïve ADHD patients indicate weaker small-worldization with decreased segregation and integration of functional brain networks. Deficits in the cingulo-fronto-parietal attention network were associated with inhibitory control deficits.
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