Evidence map›Paper›PMID 31361303›Full record

ArticleThe Journal of clinical endocrinology and metabolism2019

Plasma Agouti-Related Protein Levels in Acromegaly and Effects of Surgical or Pegvisomant Therapy.

Pamela U Freda, Carlos Reyes-Vidal, Zhezhen Jin, Mya Pugh, Sunil K Panigrahi, Jeffrey N Bruce, Sharon L Wardlaw

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. The acromegaly lipodystrophy.Frontiers in endocrinology · 2022
    Article
  5. Review
  6. Effects of growth hormone in the central nervous system.Archives of endocrinology and metabolism
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Pamela U FredaDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Carlos Reyes-VidalDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Zhezhen JinDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York.
Mya PughDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Sunil K PanigrahiDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Jeffrey N BruceDepartment of Neurosurgery, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Sharon L WardlawDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Columbia University · US

Funding

Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
New Approaches to the Evaluation and Treatment of AcromegalyR01DK064720 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FREDA, PAMELA U · 2004 to 2013
$3.8M
New Approaches to the Evaluation and Treatment of AcromegalyR01DK110771 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FREDA, PAMELA U · 2017 to 2020
$2.3M
New Approaches to the Evaluation and Treatment of AcromegalyR56DK064720 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FREDA, PAMELA U · 2015 to 2015
$229k
NCATS NIH HHS UL1 TR000040NIDDK NIH HHS R01 DK064720NIDDK NIH HHS R01 DK110771NIDDK NIH HHS R56 DK064720
6 · The paper itself

Abstract

contextGH activates agouti-related protein (AgRP) neurons, leading to orexigenic responses in mice. The relationship between serum GH and plasma AgRP, which has been shown to reflect hypothalamic AgRP, has not been evaluated in humans.

objectiveTo test the hypothesis that central stimulatory actions of GH on hypothalamic AgRP could be reflected in plasma AgRP in acromegaly.

methodsWe studied 23 patients with active acromegaly before and for ≤2 years after surgical (n = 13) or GH receptor antagonist therapy with pegvisomant (n = 10), and 100 healthy subjects with morning fasting blood samples for AgRP, leptin, GH, and IGF-1 and anthropometric measurements.

resultsThe plasma AgRP levels were higher in those with active acromegaly than in the matched healthy subjects [median, 100 pg/mL; interquartile range (IQR), 78 to 139 pg/mL vs median, 63 pg/mL; IQR, 58 to 67 pg/mL; P < 0.0001]. Plasma AgRP decreased from before to after surgery (median, 102 pg/mL; IQR, 82 to 124 pg/mL vs median, 63 pg/mL; IQR, 55.6 to 83 pg/mL; P = 0.0024) and from before to during pegvisomant therapy (median, 97 pg/mL; IQR, 77 to 175 pg/mL vs median, 63; IQR, 61 to 109 pg/mL; P = 0.006). The plasma AgRP level correlated with GH (r = 0.319; P = 0.011) and IGF-1 (r = 0.292; P = 0.002). In repeated measure analysis, AgRP was significantly associated with IGF-1.

conclusionsOur data have provided evidence of a stimulatory effect of GH on plasma AgRP in humans. The levels were greater in active acromegaly and decreased in parallel with GH and IGF-1 decreases with acromegaly treatment. Data from mice suggest that AgRP may mediate some of the known effects of GH on energy metabolism. This warrants further study in patients with acromegaly and other populations.

Indexed as

AcromegalyAdenomaAdultAgouti-Related ProteinFemaleHormone AntagonistsHuman Growth HormoneHumansInsulin-Like Growth Factor ILeptinMaleMiddle AgedNeurosurgical ProceduresPituitary NeoplasmsReceptors, SomatotropinTreatment OutcomeAgouti-Related ProteinHormone AntagonistsHuman Growth HormoneInsulin-Like Growth Factor ILeptinpegvisomantReceptors, Somatotropin

Identifiers

PMID31361303
PMCPMC6777636
OpenAlexW2965783571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.