ArticleeLife2019
Structural and functional insights into the
Abstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Computation and deep-learning-driven advances in CRISPR genome editing.Nature structural & molecular biology · 2026Review
- Learning to utilize internal protein 3D nanoenvironment descriptors in predicting CRISPR-Cas9 off-target activity.NAR genomics and bioinformatics · 2025Article
- SLC24A-mediated calcium exchange as an indispensable component of the diatom cell density-driven signaling pathway.The ISME journal · 2024Article
- Substrate-independent activation pathways of the CRISPR-Cas9 HNH nuclease.Biophysical journal · 2023Article
- Precise DNA cleavage using CRISPR-SpRYgests.Nature biotechnology · 2023Article
- The Electronic Structure of Genome Editors from the First Principles.Electronic structure (Bristol, England) · 2023Article
- Structural biology of CRISPR-Cas immunity and genome editing enzymes.Nature reviews. Microbiology · 2022Review
- Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR-Cas9.Nature catalysis · 2022Article
- Dynamics and mechanisms of CRISPR-Cas9 through the lens of computational methods.Current opinion in structural biology · 2022Review
- Lighting up Nobel Prize-winning studies with protein intrinsic disorder.Cellular and molecular life sciences : CMLS · 2022Review
- Article
- Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects.The CRISPR journal · 2022Article
- Twisting and swiveling domain motions in Cas9 to recognize target DNA duplexes, make double-strand breaks, and release cleaved duplexes.Frontiers in molecular biosciences · 2022Review
- Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence.Biochemistry · 2021Article
- Article
- The tracrRNA in CRISPR Biology and Technologies.Annual review of genetics · 2021Review
- Points of View on the Tools for Genome/Gene Editing.International journal of molecular sciences · 2021Review
- Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a.Journal of chemical information and modeling · 2020Article
- A positive, growth-based PAM screen identifies noncanonical motifs recognized by theScience advances · 2020Article
- Allosteric regulation of CRISPR-Cas9 for DNA-targeting and cleavage.Current opinion in structural biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Zhicheng ZuoDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, United States.ORCID 0000-0003-2761-5841
Ashwini ZolekarDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, United States.
Kesavan BabuDepartment of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, United States.
Victor Jt LinDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, United States.
Hamed S HayatshahiDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, United States.ORCID 0000-0001-8639-7130
Rakhi RajanDepartment of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, United States.ORCID 0000-0002-8719-4412
Yu-Chieh WangDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, United States.ORCID 0000-0002-7445-4561
Jin LiuDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, United States.ORCID 0000-0002-1067-4063
Funding
Structure-Function Studies of MsvR, a Methanogen-Specific Transcriptional RegulaP20GM103640 · NIGMS · UNIVERSITY OF OKLAHOMA · PI THOMAS, LEONARD M · 2012 to 2021
$20.4MNational Science Foundation MCB-1716423NIGMS NIH HHS P20 GM103640NIGMS NIH HHS P20GM103640Shanghai Municipal Education Commission Program for Professor of Special Appointment at Shanghai Institutions of Higher LearningUniversity of North Texas Health Science Center Start-up Fund and Basic Research Seed GrantUniversity of North Texas Health Science Center Start-up Fund and Faculty Pilot GrantUniversity of North Texas (UNT) Health Science Center Start-up Fund and Basic Research Seed GrantUniversity of North Texas (UNT) Health Science Center Start-up Fund and Faculty Pilot Grant
Abstract
The CRISPR-associated endonuclease Cas9 from
Indexed as
Catalytic DomainCRISPR-Associated Protein 9DNAMolecular Dynamics SimulationProtein BindingProtein ConformationRNA, Guide, CRISPR-Cas SystemsStreptococcus pyogenesCRISPR-Associated Protein 9DNARNA, Guide, CRISPR-Cas Systemscatalysis modelCRISPR-Cas9HEK293T cellhumanmolecular biophysicsstructural biology
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.