Evidence map›Paper›PMID 31361177›Full record

ArticleHuman vaccines & immunotherapeutics2020

Adjuvant effect of enterotoxigenic

Hyesuk Seo, Ti Lu, Sachin Mani, A Louis Bourgeois, Richard Walker, David A Sack, Weiping Zhang

Open access · hybridAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Applied and environmental microbiology · 2026
    Article
  2. Recent progress in enterotoxigenicInfection and immunity · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. A polyvalent multiepitope protein cross-protects againstProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Evaluation of Multivalent EnterotoxigenicApplied and environmental microbiology · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Confronting challenges to enterotoxigenicFrontiers in tropical diseases · 2021
    Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Hyesuk SeoDiagnostic Medicine/Pathobiology Department, Kansas State University College of Veterinary Medicine, Manhattan, KS, USA.
Ti LuDiagnostic Medicine/Pathobiology Department, Kansas State University College of Veterinary Medicine, Manhattan, KS, USA.
Sachin ManiPATH, Center for Vaccine Innovation and Access, Washington, DC, USA.ORCID 0000-0003-2974-6853
A Louis BourgeoisPATH, Center for Vaccine Innovation and Access, Washington, DC, USA.
Richard WalkerPATH, Center for Vaccine Innovation and Access, Washington, DC, USA.
David A SackDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Weiping ZhangDiagnostic Medicine/Pathobiology Department, Kansas State University College of Veterinary Medicine, Manhattan, KS, USA.
Program for Appropriate Technology in Health · USUniversity of Illinois Urbana-Champaign · USJohns Hopkins University · USKansas State University · US

Funding

A broadly protective subunit vaccine against enterotoxigenic Escherichia coli (ETEC) associateddiarrheaR01AI121067 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ZHANG, WEIPING · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI121067
6 · The paper itself

Abstract

Double-mutant heat-labile toxin (dmLT, LT

Indexed as

Bacterial ToxinsEnterotoxigenic Escherichia coliEscherichia coli InfectionsEscherichia coli ProteinsEscherichia coli VaccinesAnimalsAntibodies, BacterialAntibody FormationEnterotoxinsHot TemperatureMiceAntibodies, BacterialBacterial ToxinsEnterotoxinsEscherichia coli ProteinsEscherichia coli Vaccinesadjuvantantibody responseCFA/I/II/IV MEFADmltdose effectenterotoxigenic Escherichia coli (ETEC)

Identifiers

PMID31361177
PMCPMC7062417
OpenAlexW2964654922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.