ArticleHuman brain mapping2019
Altered transient brain dynamics in multiple sclerosis: Treatment or pathology?
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Functional Connectivity at Rest and During Cognitive Processing in Multiple Sclerosis: A Pilot Magnetoencephalography Study and Systematic Review.Brain sciences · 2026Article
- Temporally Defined Brain Network Activation Associated With Slowed Information Processing Speed in Multiple Sclerosis.Human brain mapping · 2026Article
- Task-induced 1/f slope modulation as a paradigm-independent marker of cognitive control in multiple sclerosis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Disrupted working memory event-related network dynamics in multiple sclerosis.Communications biology · 2024Article
- Brain state and dynamic transition patterns of motor imagery revealed by the bayes hidden markov model.Cognitive neurodynamics · 2024Article
- Neurophysiological avenues to better conceptualizing adaptive cognition.Communications biology · 2024Article
- Article
- The dissociative role of bursting and non-bursting neural activity in the oscillatory nature of functional brain networks.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Post-stroke upper limb recovery is correlated with dynamic resting-state network connectivity.Brain communications · 2024Article
- The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis.Human brain mapping · 2023Article
- A data-driven network decomposition of the temporal, spatial, and spectral dynamics underpinning visual-verbal working memory processes.Communications biology · 2023Article
- Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- The dynamic functional connectivity fingerprint of high-grade gliomas.Scientific reports · 2023Article
- Brain signatures of chronic gut inflammation.Frontiers in psychiatry · 2023Article
- Spontaneous transient states of fronto-temporal and default-mode networks altered by suicide attempt in major depressive disorder.European archives of psychiatry and clinical neuroscience · 2022Article
- Brain age as a surrogate marker for cognitive performance in multiple sclerosis.European journal of neurology · 2022Article
- Multi-dynamic modelling reveals strongly time-varying resting fMRI correlations.Medical image analysis · 2022Article
- Unveiling whole-brain dynamics in normal aging through Hidden Markov Models.Human brain mapping · 2022Article
- Microstates and power envelope hidden Markov modeling probe bursting brain activity at different timescales.NeuroImage · 2022Article
- Brain Volume Loss Can Occur at the Rate of Normal Aging in Patients with Multiple Sclerosis Who Are Free from Disease Activity.Journal of clinical medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
Multiple sclerosis (MS) is a demyelinating, neuroinflammatory, and -degenerative disease that affects the brain's neurophysiological functioning through brain atrophy, a reduced conduction velocity and decreased connectivity. Currently, little is known on how MS affects the fast temporal dynamics of activation and deactivation of the different large-scale, ongoing brain networks. In this study, we investigated whether these temporal dynamics are affected in MS patients and whether these changes are induced by the pathology or by the use of benzodiazepines (BZDs), an important symptomatic treatment that aims at reducing insomnia, spasticity and anxiety and reinforces the inhibitory effect of GABA. To this aim, we employed a novel method capable of detecting these fast dynamics in 90 MS patients and 46 healthy controls. We demonstrated a less dynamic frontal default mode network in male MS patients and a reduced activation of the same network in female MS patients, regardless of BZD usage. Additionally, BZDs strongly altered the brain's dynamics by increasing the time spent in the deactivating sensorimotor network and the activating occipital network. Furthermore, BZDs induced a decreased power in the theta band and an increased power in the beta band. The latter was strongly expressed in those states without activation of the sensorimotor network. In summary, we demonstrate gender-dependent changes to the brain dynamics in the frontal DMN and strong effects from BZDs. This study is the first to characterise the effect of multiple sclerosis and BZDs in vivo in a spatially, temporally and spectrally defined way.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.