Evidence map›Paper›PMID 31360866›Full record

ArticleJNCI cancer spectrum2018

Family History, Reproductive, and Lifestyle Risk Factors for Fibroadenoma and Breast Cancer.

Jingmei Li, Keith Humphreys, Peh Joo Ho, Mikael Eriksson, Eva Darai-Ramqvist, Linda Sofie Lindström, Per Hall, Kamila Czene

Open access · goldAbstract read
In one paragraph

Article in JNCI cancer spectrum, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Jingmei LiDepartment of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Keith HumphreysDepartment of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Peh Joo HoDepartment of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Mikael ErikssonDepartment of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Eva Darai-RamqvistDepartment of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Linda Sofie LindströmDepartment of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Per HallDepartment of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Kamila CzeneDepartment of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Genome Institute of Singapore · SGKarolinska Institutet · SEKarolinska University Hospital · SENational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo understand which breast cancer (BC) risk factors also increase the risk of fibroadenoma and investigate whether these factors have the same effect in BC patients with previous fibroadenoma.

methodsUsing multistate survival analysis on a large dataset (n

resultsThe mean ages at diagnosis of fibroadenoma and BC were 42.6 and 48.3 years, respectively. Participant characteristics known to increase the risk of BC were found to increase the risk of fibroadenoma (family history of BC and higher education). Participant characteristics known to confer protective effects for BC (older age at menarche, more children, and larger childhood body size) were found to reduce fibroadenoma risk. The effect sizes associated with the direct transitions from event-free to fibroadenoma and BC were generally not different for the covariates tested. Age at fibroadenoma diagnosis was associated with the transition from fibroadenoma to BC (hazard ratio

conclusionWe showed that biopsy-confirmed fibroadenomas shared many risk factors with BC. More work is needed to understand the relationships between fibroadenoma and BC to identify women who are at high risk of developing BC after a fibroadenoma diagnosis.

Identifiers

PMID31360866
PMCPMC6650060
OpenAlexW2905125175

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.