Evidence map›Paper›PMID 31360828›Full record

ArticleTH open : companion journal to thrombosis and haemostasis2019

Topically Applied Etamsylate: A New Orphan Drug for HHT-Derived Epistaxis (Antiangiogenesis through FGF Pathway Inhibition).

Virginia Albiñana, Guillermo Giménez-Gallego, Angela García-Mato, Patricia Palacios, Lucia Recio-Poveda, Angel-M Cuesta, José-Luis Patier, Luisa-María Botella

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in TH open : companion journal to thrombosis and haemostasis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05550376 (Genotype-phenotype Association Study of ENG and ACVRL1 Genes in the Inflammatory and Endothelial Response in Hereditary Hemorrhagic Telangiectasia), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05550376 completednot on this mapstarted 2021, after this paper: background citation

Genotype-phenotype Association Study of ENG and ACVRL1 Genes in the Inflammatory and Endothelial Response in Hereditary Hemorrhagic Telangiectasia (HHT)

Typeobservational_patient_registrySponsorFundacion para la Investigacion Biomedica del Hospital Universitario Ramon y CajalRan2021 to 2023Enrolled85ConditionsHereditary Hemorrhagic Telangiectasia, HHT, Rendu Osler Weber DiseaseArmsRegistry
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Virginia AlbiñanaMolecular Biomedicine Department, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Guillermo Giménez-GallegoMolecular Biomedicine Department, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Angela García-MatoMolecular Biomedicine Department, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Patricia PalaciosMolecular Biomedicine Department, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Lucia Recio-PovedaMolecular Biomedicine Department, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Angel-M CuestaMolecular Biomedicine Department, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
José-Luis PatierDepartment of Internal Medicine, University Hospital Ramón y Cajal; Department of Medicine and Medical Specialities, Faculty of Medicine, University of Alcalá, IRYCIS, Madrid, Spain.
Luisa-María BotellaMolecular Biomedicine Department, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Centro de Investigaciones Biológicas Margarita Salas · ESCentre for Biomedical Network Research on Rare Diseases · ESCentro de Investigación Biomédica en Red · ESUniversidad de Alcalá · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia characterized by recurrent and spontaneous epistaxis (nose bleeds), telangiectases on skin and mucosa, internal organ arteriovenous malformations, and dominant autosomal inheritance. Mutations in

Indexed as

Alk1antiangiogenesisEndoglinepistaxisetamsylateFGF pathwayHHTTGF-β signaling pathway

Identifiers

PMID31360828
PMCPMC6660472
OpenAlexW2965065568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.