Evidence map›Paper›PMID 31360798›Full record

ArticleAdvances in radiation oncology

Overall Survival of Breast Cancer Patients With Locoregional Failures Involving Internal Mammary Nodes.

Amy J Xu, Carl J DeSelm, Alice Y Ho, Erin F Gillespie, Lior Z Braunstein, Atif J Khan, Beryl McCormick, Simon N Powell, Oren Cahlon

Open access · goldAbstract read
In one paragraph

Article in Advances in radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Proton reirradiation for recurrent or new primary breast cancer in the setting of prior breast irradiation.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021
    Article
  6. Article
  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Amy J XuDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Carl J DeSelmDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Alice Y HoDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
Erin F GillespieDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Lior Z BraunsteinDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Atif J KhanDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Beryl McCormickDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Simon N PowellDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Oren CahlonDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Memorial Sloan Kettering Cancer Center · USMassachusetts General Hospital · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeInternal mammary node recurrence after definitive breast cancer treatment is poorly characterized, with limited data to guide clinical management. The aim of this study was to analyze the outcomes of patients with recurrent breast cancer involving internal mammary nodes to understand their natural history and determine prognostic factors associated with improved overall survival. METHODS AND MATERIALS: We performed a retrospective analysis of 553 patients with recurrent breast cancer and identified 161 patients with radiographic evidence of locoregional recurrence as a first event. A total of 67 patients (42%) were identified with internal mammary involvement. Median follow-up times were 76 months from date of initial diagnosis and 30 months from date of recurrence.

resultsOf the 67 patients identified with internal mammary node failures, 10 (15%) presented with isolated recurrence, 14 (21%) presented with other sites of locoregional disease, and 43 (64%) presented with concomitant distant metastases. Median overall survival was 2.5 years and significantly associated with extent of disease (

conclusionsPatients with isolated internal mammary node recurrences achieved long-term survival with aggressive therapies, and salvage radiation therapy was associated with improved survival.

Identifiers

PMID31360798
PMCPMC6639740
OpenAlexW2919118245

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.