Evidence map›Paper›PMID 31360769›Full record

ArticleScience advances2019

Two-dimensional nuclear magnetic resonance spectroscopy with a microfluidic diamond quantum sensor.

Janis Smits, Joshua T Damron, Pauli Kehayias, Andrew F McDowell, Nazanin Mosavian, Ilja Fescenko, Nathaniel Ristoff, Abdelghani Laraoui, Andrey Jarmola, Victor M Acosta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 124 citations in OpenAlex.

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  17. Quantum sensors for biomedical applications.Nature reviews. Physics · 2023
    Review
  18. Large Room Temperature Bulk DNP ofThe journal of physical chemistry. C, Nanomaterials and interfaces · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Janis SmitsCenter for High Technology Materials and Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87106, USA.ORCID 0000-0002-5835-9345
Joshua T DamronCenter for High Technology Materials and Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87106, USA.ORCID 0000-0003-3409-0190
Pauli KehayiasCenter for High Technology Materials and Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87106, USA.ORCID 0000-0002-7597-4358
Andrew F McDowellNuevoMR LLC, Albuequerque, NM 87106, USA.
Nazanin MosavianCenter for High Technology Materials and Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87106, USA.
Ilja FescenkoCenter for High Technology Materials and Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87106, USA.
Nathaniel RistoffCenter for High Technology Materials and Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87106, USA.ORCID 0000-0001-6829-0049
Abdelghani LaraouiCenter for High Technology Materials and Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87106, USA.ORCID 0000-0002-2811-8030
Andrey JarmolaDepartment of Physics, University of California, Berkeley, CA 94720, USA.ORCID 0000-0001-5439-1324
Victor M AcostaCenter for High Technology Materials and Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87106, USA.ORCID 0000-0003-0058-9954
University of New Mexico · USInstituto Português de Malacologia · PTMMR Technologies (United States) · US

Funding

Microfluidic diamond NMR sensorR41GM130239 · NIGMS · ODMR TECHNOLOGIES, INC. · PI ACOSTA, VICTOR MARCEL, JARMOLA, ANDREJS · 2018 to 2018
$225k
NIGMS NIH HHS R41 GM130239
6 · The paper itself

Abstract

Quantum sensors based on nitrogen-vacancy centers in diamond have emerged as a promising detection modality for nuclear magnetic resonance (NMR) spectroscopy owing to their micrometer-scale detection volume and noninductive-based detection. A remaining challenge is to realize sufficiently high spectral resolution and concentration sensitivity for multidimensional NMR analysis of picoliter sample volumes. Here, we address this challenge by spatially separating the polarization and detection phases of the experiment in a microfluidic platform. We realize a spectral resolution of 0.65 ± 0.05 Hz, an order-of-magnitude improvement over previous diamond NMR studies. We use the platform to perform two-dimensional correlation spectroscopy of liquid analytes within an effective ∼40-picoliter detection volume. The use of diamond quantum sensors as in-line microfluidic NMR detectors is a major step toward applications in mass-limited chemical analysis and single-cell biology.

Identifiers

PMID31360769
PMCPMC6660203
OpenAlexW2965884541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.