Evidence map›Paper›PMID 31360724›Full record

Trial reportBioMed research international2019

One-Year Efficacy and Safety of Combined Photorefractive Keratectomy and Accelerated Corneal Collagen Cross-Linking after Intacs SK Intracorneal Ring Segment Implantation in Moderate Keratoconus.

Il Hwan Koh, Kyoung Yul Seo, Seong Bae Park, Hun Yang, InSik Kim, Jin Sun Kim, David G Hwang, Sang Min Nam

Registry-linked trialOpen access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04383301 (Combined Corneal Wavefront-guided Transepithelial Photorefractive Keratectomy and Accelerated Corneal Collagen Cross-linking Following Intra Corneal Ring Segment Implantation in Management of Moderate Keratoconus), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04383301 nacompletednot on this map

Combined Corneal Wavefront-guided Transepithelial Photorefractive Keratectomy and Accelerated Corneal Collagen Cross-linking Following Intra Corneal Ring Segment Implantation in Management of Moderate Keratoconus

TypeinterventionalSponsorShaaban ElwanRan2018 to 2020Enrolled36ConditionsKeratoconusArmsIntracorneal ring segment implantaion as the first stage, ACXL and wafe front guieded TPRK as the second stage
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Il Hwan KohSU Yonsei Eye Clinic, Seoul, Republic of Korea.
Kyoung Yul SeoDepartment of Ophthalmology, Institute of Vision Research, Eye and Ear Hospital, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-9855-1980
Seong Bae ParkSU Yonsei Eye Clinic, Seoul, Republic of Korea.
Hun YangSU Yonsei Eye Clinic, Seoul, Republic of Korea.
InSik KimSU Yonsei Eye Clinic, Seoul, Republic of Korea.
Jin Sun KimSU Yonsei Eye Clinic, Seoul, Republic of Korea.
David G HwangCornea Service and Refractive Surgery Service, Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Sang Min NamDepartment of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.ORCID https://orcid.org/0000-0001-6903-6333
CHA University Bundang Medical Center · KRUniversity of California, San Francisco · USYonsei University · KR

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
NEI NIH HHS P30 EY002162
6 · The paper itself

Abstract

purposeTo report one-year outcomes of a modified version of two-stage multimodal surgical protocol for moderate keratoconus which has been suggesting promising preliminary results. MATERIALS AND

methods30 eyes of 25 patients with moderate keratoconus who exhibited visual complaints and/or disease progression were included for this retrospective case study. Approximately 3 months after implantation of intracorneal ring segment (Intacs SK™), a combination of corneal wavefront-guided transepithelial photorefractive keratectomy (CWG-transPRK, Schwind Amaris® 1050, and Schwind Sirius) and accelerated collagen cross-linking (accCXL, Avedro KXL™) was performed. Patients were examined for uncorrected and corrected distance visual acuity (UDVA; CDVA), keratometric power (K), corneal thickness, and corneal higher-order aberrations (HOAs) preoperatively and at postoperative 1, 3, 6, and 12 months.

resultsThe median UDVA and mean CDVA were enhanced from 6/38 to 6/12 and from 6/19 to 6/7.5, respectively, through 12 months after CWG-transPRK/accCXL. The 12-month CDVA of all patients was better than 6/12 Snellen, and no subject lost one or more lines of CDVA. The magnitudes of both myopia and corneal steepness were decreased in turn by Intacs SK implantation and also by CWG-transPRK/accCXL, but the reduction in HOA was largely the result of CWG-transPRK/accCXL. The magnitude of corneal thinning stabilized within 3 months after CWG-transPRK/accCXL.

conclusionThis approach may allow patients with moderate keratoconus to obtain satisfactory vision without the need for contact lens wear. This surgery appeared to be effective and safe through 1 year of follow-up.

Indexed as

Corneal StromaCorneal TopographyKeratoconusPhotorefractive KeratectomySafetyVisual AcuityAdultCollagenFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesCollagen

Identifiers

PMID31360724
PMCPMC6644267
OpenAlexW2959262125

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.