SynthesisBioMed research international2019
Maternal Body Mass Index and Risk of Congenital Heart Defects in Infants: A Dose-Response Meta-Analysis.
Synthesis in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Maternal modifiable factors and risk of congenital heart defects: systematic review and causality assessment.BMJ open · 2024Pooled it
- The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review.Frontiers in endocrinology · 2022Pooled it
- Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review.PloS one · 2021Pooled it
- [Obesity during pregnancy is associated to congenital cardiopathies in the newborn].Revista medica del Instituto Mexicano del Seguro Social · 2026Article
- [Expert consensus on the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: congenital heart disease (2025)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Role of Maternal Obesity in Offspring Cardiovascular Development and Congenital Heart Defects.Journal of the American Heart Association · 2025Article
- Maternal Diabetes and Overweight and Congenital Heart Defects in Offspring.JAMA network open · 2024Article
- Association of congenital heart defects (CHD) with factors related to maternal health and pregnancy in newborns in Puerto Rico.Congenital heart disease · 2024Article
- The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomisation study.BMC medicine · 2023Article
- [Preventive activities in women. PAPPS update 2022].Atencion primaria · 2022Article
- Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring.The Proceedings of the Nutrition Society · 2022Review
- Trends in maternal body mass index in Northern Ireland: a cross-sectional and longitudinal study.Family medicine and community health · 2021Article
- Effect of Maternal Prepregnancy/Early-Pregnancy Body Mass Index and Pregnancy Smoking and Alcohol on Congenital Heart Diseases: A Parental Negative Control Study.Journal of the American Heart Association · 2021Article
- The effect of maternal pre-/early-pregnancy BMI and pregnancy smoking and alcohol on congenital heart diseases: a parental negative control study.medRxiv : the preprint server for health sciences · 2020Article
- [Preventive activities in women's care].Atencion primaria · 2020Article
- Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring.Journal of the American Heart Association · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe exact shape of the dose-response relationship between maternal body mass index (BMI) and the risk of congenital heart defects (CHDs) in infants has not been clearly defined yet. This study aims to further clarify the relationship between maternal obesity and the risk of CHDs in infants by an overall and dose-response meta-analysis.
methodsPubMed, Embase, and Web of Science databases were searched to identify all related studies. The studies were limited to human cohort or case-control studies in English language. Random-effect models and dose-response meta-analysis were used to synthesize the results. Heterogeneity, subgroup analysis, sensitivity analysis, and publication bias were also assessed.
resultsNineteen studies with 2,416,546 participants were included in our meta-analysis. Compared with the mothers with normal weight, the pooled relative risks (RRs) of infants with CHDs were 1.08 (95% CI=1.03-1.13) in overweight and 1.23 (95% CI=1.17-1.29) in obese mothers. According to the findings from the linear meta-analysis, we observed an increased risk of infants with CHDs (RR=1.07, 95% CI=1.06-1.08) for each 5 kg/m
conclusionThe results from our meta-analysis indicate that increased maternal BMI is related to increased risk of CHDs in infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.