ArticleBiomedical optics express2019
Automated retinal microvascular velocimetry based on erythrocyte mediated angiography.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Plexus-Specific Retinal Capillary Blood Flow Analysis Using Erythrocyte Mediated Angiography and Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2024Article
- Measurement of retinal blood flow precision in the human eye with multimodal adaptive optics imaging.Biomedical optics express · 2024Article
- MEMO: dataset and methods for robust multimodal retinal image registration with large or small vessel density differences.Biomedical optics express · 2024Article
- Article
- A Pilot Study Assessing Retinal Blood Flow Dysregulation in Glaucoma Using Erythrocyte Mediated Velocimetry.Translational vision science & technology · 2022Article
- Morphological Characteristics, Hemoglobin Content, and Membrane Mechanical Properties of Red Blood Cell Delivery Systems.ACS applied materials & interfaces · 2022Article
- Membrane Cholesterol Enrichment of Red Blood Cell-Derived Microparticles Results in Prolonged Circulation.ACS applied bio materials · 2022Article
- In Vivo Capillary Structure and Blood Cell Flux in the Normal and Diabetic Mouse Eye.Investigative ophthalmology & visual science · 2022Article
- Current and novel multi-imaging modalities to assess retinal oxygenation and blood flow.Eye (London, England) · 2021Review
- Phototheranostics Using Erythrocyte-Based Particles.Biomolecules · 2021Review
- Measurement of Retinal Microvascular Blood Velocity Using Erythrocyte Mediated Velocimetry.Scientific reports · 2019Article
- OCTA in neurodegenerative optic neuropathies: emerging biomarkers at the eye-brain interface.Therapeutic advances in ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Retinal blood flow is an emerging biomarker in ocular and systemic disease. Erythrocyte mediated angiography (EMA) is a novel technique that provides an easily interpretable blood flow velocity quantification by directly tracing individual moving erythrocyte ghosts over time in vivo, imaged using a scanning laser ophthalmoscope (Heidelberg Retina Angiograph platform). This tracking procedure, however, requires time-consuming manual analysis to determine blood flow. To overcome this current bottleneck, we developed an objective and automated velocimetry approach, EMA - Automated Velocimetry (EMA-AV), which is based on a modified sequential Monte Carlo method. The intra-class correlation coefficient (ICC) between trained human graders and EMA-AV is 0.98 for mean vessel velocity estimation and 0.92 for frame by frame erythrocyte velocity estimation. This study proves EMA-AV is a reliable tool for quantification of retinal microvascular velocity and flow and establishes EMA-AV as a reliable and interpretable tool for quantifying retinal microvascular velocity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.