ArticleBiomedical optics express2019
Three-dimensional structural and angiographic evaluation of foveal ischemia in diabetic retinopathy: method and validation.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Efficacy of conbercept pro re nata (PRN) versus treat-and-extend (T&E) regimens following five initial monthly doses in diabetic macular edema: a 24-month retrospective cohort study.Frontiers in endocrinology · 2026Article
- Relationship Between Foveal Avascular Zone Measured by Optical Coherence Tomography Angiography and Visual Acuity in Diabetic Retinopathy: A Systematic Review.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Clinical characterization of 3-year progression of diabetic macular ischemia on OCT angiography.Japanese journal of ophthalmology · 2026Article
- Longitudinal changes in anatomic biomarkers on optical coherence tomography angiography in diabetic retinopathy.Frontiers in ophthalmology · 2026Article
- Image-processing pipeline for diagnosing diabetic macular ischaemia in diabetic macular oedema.Scientific reports · 2025Article
- Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023Review
- Volumetrically tracking retinal and choroidal structural changes in central serous chorioretinopathy.Biomedical optics express · 2023Article
- OCT angiography and its retinal biomarkers [Invited].Biomedical optics express · 2023Review
- Study of Foveal Avascular Zone Growth in Individuals With Mild Diabetic Retinopathy by Optical Coherence Tomography.Investigative ophthalmology & visual science · 2023Article
- Ganglion Cell Complex Analysis: Correlations with Retinal Nerve Fiber Layer on Optical Coherence Tomography.Diagnostics (Basel, Switzerland) · 2023Review
- Volume-based, layer-independent, disease-agnostic detection of abnormal retinal reflectivity, nonperfusion, and neovascularization using structural and angiographic OCT.Biomedical optics express · 2022Article
- Towards standardizing retinal optical coherence tomography angiography: a review.Light, science & applications · 2022Review
- Artificial intelligence in OCT angiography.Progress in retinal and eye research · 2021Review
- Cognitive decline in older adults: What can we learn from optical coherence tomography (OCT)-based retinal vascular imaging?Journal of the American Geriatrics Society · 2021Article
- Past, present and future role of retinal imaging in neurodegenerative disease.Progress in retinal and eye research · 2021Review
- Quantification of Nonperfusion Area in Montaged Widefield OCT Angiography Using Deep Learning in Diabetic Retinopathy.Ophthalmology science · 2021Article
- Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography.Progress in retinal and eye research · 2021Review
- Article
- 3D Retinal Vessel Density Mapping With OCT-Angiography.IEEE journal of biomedical and health informatics · 2020Article
- Real-time retinal layer segmentation of OCT volumes with GPU accelerated inferencing using a compressed, low-latency neural network.Biomedical optics express · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Optical coherence tomography angiography (OCTA) allows us to noninvasively investigate foveal ischemia, a key feature of diabetic retinopathy (DR). However, the sizes of the foveal avascular zone (FAZ) have a significant variation in normal population, preventing the objective assessment of pathological enlargement of FAZ due to capillary dropout. Based on the relationship between FAZ and ganglion cell complex (GCC) thickness in normal eyes, we defined a theoretical baseline FAZ (tbFAZ) on structural OCT and measured 2D and 3D vessel density in its vicinity on the simultaneously acquired OCTA in normal and diabetic eyes. We found that the structure-based tbFAZ was a reliable reference to identify foveal ischemia and that the 3D vessel density demonstrated ischemia more effectively than the 2D method. The proposed 3D para-FAZ vessel density correlates well with DR severity and potentially is a useful diagnostic biomarker, especially in the early stages of DR.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.