Evidence map›Paper›PMID 31360597›Full record

ArticleBiomedical optics express2019

Changes in the crystallographic structures of cardiac myosin filaments detected by polarization-dependent second harmonic generation microscopy.

Cai Yuan, Zhonghai Wang, Thomas K Borg, Tong Ye, Catalin Baicu, Amy Bradshaw, Michael Zile, Raymond B Runyan, Yonghong Shao, Bruce Z Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Cai YuanDepartment of Bioengineering, Clemson University, Clemson, South Carolina, 29634, USA.
Zhonghai WangDepartment of Bioengineering, Clemson University, Clemson, South Carolina, 29634, USA.
Thomas K BorgDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina Charleston, South Carolina, 29425, USA.
Tong YeDepartment of Bioengineering, Clemson University, Clemson, South Carolina, 29634, USA.
Catalin BaicuDepartment of Medicine, Medical University of South Carolina, Charleston, South Carolina, 29425, USA.
Amy BradshawDepartment of Medicine, Medical University of South Carolina, Charleston, South Carolina, 29425, USA.
Michael ZileDepartment of Medicine, Medical University of South Carolina, Charleston, South Carolina, 29425, USA.
Raymond B RunyanDepartment of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona, 85724, USA.
Yonghong ShaoCollege of Optoelectronics Engineering, Shenzhen University, Shenzhen, 518061, China.
Bruce Z GaoDepartment of Bioengineering, Clemson University, Clemson, South Carolina, 29634, USA.
Clemson University · USMedical University of South Carolina · USShenzhen University · CN

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Tissue Structural and Neural Remodeling in Human Sacroiliac JointP20GM121342 · NIGMS · CLEMSON UNIVERSITY · PI Hai Yao · 2018 to 2026
$24.7M
UNDERSTANDING AND CONTROLLING TISSUE-SPECIFIC VASCULAR PATTERNINGP20RR021949 · NCRR · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R · 2009 to 2011
$5.2M
Systems Mechanobiology Modeling for Patient-Specific Cardiac Fibrosis PredictionsR01HL144927 · NHLBI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI RICHARDSON, WILLIAM JAMES · 2019 to 2023
$1.8M
Microfabricated coculture model: Myocyte rescue by TNT-transferred mitochondriaR01HL124782 · NHLBI · CLEMSON UNIVERSITY · PI GAO, BRUCE Z, RUNYAN, RAYMOND BRUCE · 2014 to 2017
$1.5M
NCRR NIH HHS P20 RR021949NHLBI NIH HHS R01 HL124782NHLBI NIH HHS R01 HL144927NIEHS NIH HHS P30 ES006694NIGMS NIH HHS P20 GM121342
6 · The paper itself

Abstract

Detecting the structural changes caused by volume and pressure overload is critical to comprehending the mechanisms of physiologic and pathologic hypertrophy. This study explores the structural changes at the crystallographic level in myosin filaments in volume- and pressure-overloaded myocardia through polarization-dependent second harmonic generation microscopy. Here, for the first time, we report that the ratio of nonlinear susceptibility tensor components

Identifiers

PMID31360597
PMCPMC6640825
OpenAlexW2948941207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.