ArticleEcho research and practice2019
Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO): echocardiography performance protocol.
Article in Echo research and practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01934725 (Searching for Explanations for Cryptogenic Stroke in the Young), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO)
Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Left ventricular non-compaction as a potential source for cryptogenic ischemic stroke in the young: A case-control study.PloS one · 2020Trial
- Association Between Recent Mechanical Risk Factors for Venous Thrombosis and Young-Onset Cryptogenic Ischemic Stroke.Stroke · 2026Article
- Cardiac Organ Damage in Young Adults with Cryptogenic Ischaemic Stroke: The SECRETO Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Acute non-alcoholic caffeinated beverage consumption as a trigger for cryptogenic ischemic stroke in the young: findings from the SECRETO study.Journal of neurology · 2026Observational
- Association Between Physical Activity and Cryptogenic Ischemic Stroke in Young Adults: A Case-Control Study.European journal of neurology · 2026Article
- Anti-beta2-glycoprotein I IgG antibodies are associated with early-onset cryptogenic ischemic stroke.European stroke journal · 2026Article
- Anti-beta2-glycoprotein I IgG antibodies are associated with early-onset cryptogenic ischemic stroke.European stroke journal · 2025Article
- Burden of Modifiable Risk Factors in Young-Onset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale.Stroke · 2025Observational
- Association Between Self-Perceived Stress and Cryptogenic Ischemic Stroke in Young Adults: A Case-Control Study.Neurology · 2025Article
- Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: a case-control study.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- Multimodality Cardiac Imaging in Ischemic Stroke: Insights into the Heart-Brain Interaction.Cardiology · 2025Review
- Association of Left Atrial Stiffness With Risk of Cryptogenic Ischemic Stroke in Young Adults.JACC. Advances · 2024Article
- 24-hour ambulatory blood pressure and cryptogenic ischemic stroke in young adults.Annals of medicine · 2023Article
- MRI-derived cardiac washout is slowed in the left ventricle and associated with left ventricular non-compaction in young patients with cryptogenic ischemic stroke.The international journal of cardiovascular imaging · 2022Article
- Endothelial Dysfunction is Associated With Early-Onset Cryptogenic Ischemic Stroke in Men and With Increasing Age.Journal of the American Heart Association · 2021Article
- Article
- Left Atrial Dynamics Is Altered in Young Adults With Cryptogenic Ischemic Stroke: A Case-Control Study Utilizing Advanced Echocardiography.Journal of the American Heart Association · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of ischemic stroke in young patients is increasing and associated with unfavorable prognosis due to high risk of recurrent cardiovascular events. In many young patients the cause of stroke remains unknown, referred to as cryptogenic stroke. Neuroimaging frequently suggests a proximal source of embolism in these strokes. We developed a comprehensive step-by-step echocardiography protocol for a prospective study with centralized reading to characterize preclinical cardiac changes associated with cryptogenic stroke. METHODS AND STUDY
designSECRETO (Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome; NCT01934725) is an ongoing multicenter case-control study enrolling patients (target
conclusionsA detailed assessment of both conventional and unconventional vascular risk factors and cardiac imaging with transthoracic and transesophageal echocardiography are implemented in SECRETO, aiming to establish indirect and direct risk factors and causes for cryptogenic stroke and novel pathophysiological brain-heart pathways. This may ultimately enable more personalized therapeutic options for these patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.