Evidence map›Paper›PMID 31360502›Full record

ArticleClinical case reports2019

Successful determination of nilotinib dosage by therapeutic drug monitoring in a patient with chronic myeloid leukemia developing hepatic dysfunction: A case report.

Ryosuke Nakahara, Takahiro Sumimoto, Masao Ogata, Yuhki Sato, Hiroki Itoh

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Therapeutic drug monitoring of oral targeted antineoplastic drugs.European journal of clinical pharmacology · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryosuke NakaharaDepartment of Clinical Pharmacy Oita University Hospital Yufu-shi Japan.ORCID https://orcid.org/0000-0001-5365-8664
Takahiro SumimotoDepartment of Clinical Pharmacy Oita University Hospital Yufu-shi Japan.
Masao OgataDepartment of Hematology Oita University Hospital Yufu-shi Japan.
Yuhki SatoDepartment of Clinical Pharmacy Oita University Hospital Yufu-shi Japan.
Hiroki ItohDepartment of Clinical Pharmacy Oita University Hospital Yufu-shi Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fixed dosage regimen is currently the standard therapy with tyrosine kinase inhibitors (TKI). This case report demonstrates successful determination of nilotinib dosage by therapeutic drug monitoring (TDM) in a patient with chronic myeloid leukemia (CML). TDM may provide useful marker for individualized dosing of TKI for the treatment of CML.

Indexed as

chronic myeloid leukemiahepatic dysfunctionnilotinibtherapeutic drug monitoring

Identifiers

PMID31360502
PMCPMC6637326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.