Evidence map›Paper›PMID 31360402›Full record

ArticleChemical science2019

Probing and regulating the activity of cellular enzymes by using DNA tetrahedron nanostructures.

Yi Zhang, Yingnan Deng, Congshan Wang, Lidan Li, Lida Xu, Yingjie Yu, Xin Su

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 99 citations in OpenAlex.

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  12. Characterization of DNA nanostructure stability by size exclusion chromatography.Analytical methods : advancing methods and applications · 2022
    Article
  13. Article
  14. Recent Advances on Functional Nucleic-Acid Biosensors.Sensors (Basel, Switzerland) · 2021
    Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yi ZhangCollege of Life Science and Technology , Beijing University of Chemical Technology , Beijing 100029 , China . Email: xinsu@mail.buct.edu.cn.
Yingnan DengCollege of Life Science and Technology , Beijing University of Chemical Technology , Beijing 100029 , China . Email: xinsu@mail.buct.edu.cn.
Congshan WangCollege of Life Science and Technology , Beijing University of Chemical Technology , Beijing 100029 , China . Email: xinsu@mail.buct.edu.cn.
Lidan LiCollege of Life Science and Technology , Beijing University of Chemical Technology , Beijing 100029 , China . Email: xinsu@mail.buct.edu.cn.
Lida XuCollege of Life Science and Technology , Beijing University of Chemical Technology , Beijing 100029 , China . Email: xinsu@mail.buct.edu.cn.
Yingjie YuDepartment of Biomedical Engineering , Tufts University , Medford , MA 02155 , USA . Email: yuyingjie312@outlook.com.
Xin SuCollege of Life Science and Technology , Beijing University of Chemical Technology , Beijing 100029 , China . Email: xinsu@mail.buct.edu.cn.ORCID 0000-0002-6629-9856
Beijing University of Chemical Technology · CNTufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the essential role of apurinic/apyrimidinic endonuclease (APE1) in gene repair and cancer progression, we report a novel approach for probing and regulating cellular APE1 activity by using DNA tetrahedrons. The tetrahedron with an AP site-containing antenna exhibits high sensitivity and specificity to APE1. It is suitable for APE1

Identifiers

PMID31360402
PMCPMC6566069
OpenAlexW2942521757

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.