ReviewPain research & management2019
Risk Factors and Prevention Strategies for Postoperative Opioid Abuse.
Review in Pain research & management, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04687501 (The Effect of Virtual Reality on Anxiety and Pain in Patients Undergoing Gynecological Surgery; a Randomised Controlled Trial), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Virtual Reality on Anxiety and Pain in Patients Undergoing Gynecological Surgery; a Randomised Controlled Trial
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Analgesic drug efficacy in mouse postoperative pain: a systematic review and meta-analysis.Lab animal · 2026Pooled it
- High-dose steroids in high pain responders undergoing total knee arthroplasty: a randomised double-blind trial.British journal of anaesthesia · 2022Trial
- Disparities and burden of illness among hospitalized cancer patients with opioid dependence.Medical oncology (Northwood, London, England) · 2026Article
- Non-Tobacco Nicotine Is Associated With Increased Complications Following Posterior Cervical Fusion: A Retrospective Cohort Study.Global spine journal · 2026Article
- Role of Pain in Adults Undergoing Soft Tissue and Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea.Laryngoscope investigative otolaryngology · 2025Article
- Non-tobacco nicotine dependence increases risk of complications following lumbar spine decompression and fusion.North American Spine Society journal · 2025Article
- Efficacy and safety of the pudendal nerve block as a component of multimodal analgesia for cervical brachytherapy.Clinical and translational radiation oncology · 2025Article
- Effective Use of Topical Ketamine in Managing Acute Post-Operative Pain Following Fournier's Gangrene Surgery: A Case Report.Clinical case reports · 2025Article
- Disparities in Postoperative Pain Management: A Scoping Review of Prescription Practices and Social Determinants of Health.Pharmacy (Basel, Switzerland) · 2025Review
- The Genetic Association Between Prescription Pain Medication Use and the Risk for Fibromyalgia: A Bidirectional and Multivariable Mendelian Randomization Analysis.Journal of pain research · 2025Article
- Associations Among Sleep, Pain, and Medications for Opioid Use Disorder: a Scoping Review.Current addiction reports · 2024Article
- Enhanced Recovery Protocol Decreases Postoperative Opioid Use after Penile Inversion Vaginoplasty.Plastic and reconstructive surgery. Global open · 2024Article
- A Machine Learning Application to Classify Patients at Differing Levels of Risk of Opioid Use Disorder: Clinician-Based Validation Study.JMIR medical informatics · 2024Article
- Acute Pain and Development of Opioid Use Disorder: Patient Risk Factors.Current pain and headache reports · 2023Review
- Postoperative opioid-prescribing practices in otolaryngology: Evidence-based guideline outcomes.Laryngoscope investigative otolaryngology · 2023Article
- Emulsion-induced polymersomes taming tetrodotoxin for prolonged duration local anesthesia.Advanced therapeutics · 2023Article
- Preoperative Patient-Reported Data Indicate the Risk of Prolonged Opioid Use After Hand and Upper Extremity Surgeries.The Journal of hand surgery · 2022Article
- Persistent opioid use in cataract surgery pain management and the role of nonopioid alternatives.Journal of cataract and refractive surgery · 2022Article
- Effect of Perioperative Opioid Use on Patients Undergoing Hip Arthroscopy.Orthopaedic journal of sports medicine · 2022Article
- Naltrexone Implant for Opioid Use Disorder.Neurology international · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Worldwide, 80% of patients who undergo surgery receive opioid analgesics as the fundamental agent for pain relief. However, the irrational use of opioids leads to excessive drug dependence and drug abuse, resulting in an increased mortality rate and huge economic loss. The crisis of opioid overuse remains a great challenge. In this review, we summarize several key factors in opioid abuse, including race, region, income, genetic factors, age and gender, smoking and alcohol abuse, history of chronic pain and analgesic drug abuse, surgery, neuropsychiatric illness, depression and antidepressant use, human factors, national policies, hospital regulations, and health insurance under treatment of pain. Furthermore, we present several prevention strategies, such as perioperative measures, opioid substitutes, treatment of the primary illness, emotional regulation, use of opioid antagonists, efforts of the state, hospitals, doctors and pharmacy benefit managers, gene therapy, and vaccines. Greater understanding and better assessment are required of the risks associated with opioid abuse to ensure the safety and analgesic effects of pain treatment after surgery.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.