Evidence map›Paper›PMID 31360262›Full record

ArticleDisease markers2019

Characterization of T-Cell Receptor Repertoire in Patients with Rheumatoid Arthritis Receiving Biologic Therapies.

Che-Mai Chang, Yu-Wen Hsu, Henry Sung-Ching Wong, James Cheng-Chung Wei, Xiao Liu, Hsien-Tzung Liao, Wei-Chiao Chang

Abstract read
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Long Non-Coding RNAsCurrent issues in molecular biology · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. T Cell Abnormalities in X-Linked Agammaglobulinaemia: an Updated Review.Clinical reviews in allergy & immunology · 2023
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. International journal of environmental research and public health · 2020
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Che-Mai ChangPh.D. Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan.ORCID https://orcid.org/0000-0002-0353-9744
Yu-Wen HsuPh.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 115, Taiwan.
Henry Sung-Ching WongDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
James Cheng-Chung WeiInstitute of Medicine, Chung Shan Medical University, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.ORCID https://orcid.org/0000-0002-1235-0679
Xiao LiuDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
Hsien-Tzung LiaoDivision of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan.ORCID https://orcid.org/0000-0001-5930-4840
Wei-Chiao ChangDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.ORCID https://orcid.org/0000-0002-8573-5924

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a systematic autoimmune disease, predominantly causing chronic polyarticular inflammation and joint injury of patients. For the treatment of RA, biologic disease-modifying antirheumatic drugs (bDMARDs) have been used to reduce inflammation and to interfere with disease progression through targeting and mediating the immune system. Although the therapeutic effects of bDMARDs in RA patients have been widely reported, whether these drugs also play important roles in T-cell repertoire status is still unclear. We therefore designed the study to identify the role of T-cell repertoire profiles in RA patients with different types of bDMARD treatments. A high-throughput sequencing approach was applied to profile the T-cell receptor beta chain (TCRB) repertoire of circulating T lymphocytes in eight patients given adalimumab (anti-TNF-

Indexed as

AdultAgedAntirheumatic AgentsArthritis, RheumatoidBiological TherapyBiomarkersCase-Control StudiesDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisReceptors, Antigen, T-CellTumor Necrosis Factor-alphaAntirheumatic AgentsBiomarkersReceptors, Antigen, T-CellTumor Necrosis Factor-alpha

Identifiers

PMID31360262
PMCPMC6642763

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.