Evidence map›Paper›PMID 31360224›Full record

ArticleTherapeutic advances in gastroenterology2019

Can advanced endoscopic techniques for assessment of mucosal inflammation and healing approximate histology in inflammatory bowel disease?

Olga Maria Nardone, Rosanna Cannatelli, Davide Zardo, Subrata Ghosh, Marietta Iacucci

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. New Technologies for IBD Endoscopy.Journal of clinical medicine · 2026
    Review
  3. Artificial intelligence in the management of inflammatory bowel disease: What's next?World journal of gastrointestinal pharmacology and therapeutics · 2026
    Review
  4. Review
  5. Present and future of endoscopy precision for inflammatory bowel disease.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2024
    Review
  6. AI and endoscopy/histology in UC: the rise of machine.Therapeutic advances in gastroenterology · 2024
    Review
  7. Review
  8. Article
  9. New endoscopic tools in inflammatory bowel disease.United European gastroenterology journal · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. United European gastroenterology journal · 2020
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Olga Maria NardoneInstitute of Translational Medicine and Institute of Immunology and Immunotherapy, University of Birmingham, Heritage Building, Mindelsohn Way, Birmingham, B15 2TH, UK.ORCID 0000-0002-9554-4785
Rosanna CannatelliInstitute of Translational Medicine and Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Davide ZardoUniversity Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK.
Subrata GhoshInstitute of Translational Medicine and Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Marietta IacucciInstitute of Translational Medicine and Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
University Hospitals Birmingham NHS Foundation Trust · GBUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The targets of therapy in inflammatory bowel disease have transformed in the last few years. The standard definition of mucosal healing assessed using white light standard definition endoscopy is being challenged because even when endoscopy suggests mucosal healing, the presence of histological activity can often still be observed. Of note, microscopic signs of inflammation correlate with clinical outcomes such as risk of relapse, hospitalization and colorectal cancer. Therefore, histological healing has increasingly become an important target to achieve. Advanced endoscopic technologies have been developed and many are starting to be adopted in daily clinical practice. They can provide a more detailed view of the mucosal and vascular architecture almost at the histology level, including crypt, vessel architecture and cellular infiltration. So, these can provide a more accurate definition of mucosal and histological healing. In this review we focus on new advanced endoscopic techniques, and how these have the potential to reduce the gap between histological and mucosal healing.

Indexed as

advanced endoscopic techniquesCrohn’s diseaseelectronic virtual chromoendoscopyhistological healingmucosal healingUlcerative colitis

Identifiers

PMID31360224
PMCPMC6640057
OpenAlexW2962999280

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.