ArticleTherapeutic advances in gastroenterology2019
The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database.
Article in Therapeutic advances in gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 27 citations in OpenAlex.
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- The survival impact of palliative radiotherapy on synchronous metastatic pancreatic ductal adenocarcinoma: metastatic site can serve for radiotherapy-decision.Journal of Cancer · 2022Article
- Accurate nomograms with excellent clinical value for locally advanced rectal cancer.Annals of translational medicine · 2021Article
- Has the increase in the regional nodes evaluated improved survival rates for patients with locoregional colon cancer?Journal of Cancer · 2021Article
- A novel risk-scoring system conducing to chemotherapy decision for patients with pancreatic ductal adenocarcinoma after pancreatectomy.Journal of Cancer · 2021Article
- The Survival Effect of Radiotherapy on Stage II/III Rectal Cancer in Different Age Groups: Formulating Radiotherapy Decision-Making Based on Age.Frontiers in oncology · 2021Article
- Follistatin-Like 3 Enhances Invasion and Metastasis via β-Catenin-Mediated EMT and Aerobic Glycolysis in Colorectal Cancer.Frontiers in cell and developmental biology · 2021Article
- Development and validation of prognostic nomograms for early-onset locally advanced colon cancer.Aging · 2020Article
- Comparable prevalence of distant metastasis and survival of different primary site for LN + pancreatic tumor.Journal of translational medicine · 2020Article
- The Main Bottleneck for Non-Metastatic Pancreatic Adenocarcinoma in Past Decades: A Population-Based Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Nonadherence to Standard of Care for Locally Advanced Colon Cancer as a Contributory Factor for High Mortality Rates in Kentucky.Journal of the American College of Surgeons · 2020Article
- Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based Analysis.Gastroenterology research and practice · 2020Article
- Nomograms predicting Overall Survival and Cancer-specific Survival for Synchronous Colorectal Liver-limited Metastasis.Journal of Cancer · 2020Article
- A bibliometric analysis of 23,492 publications on rectal cancer by machine learning: basic medical research is needed.Therapeutic advances in gastroenterology · 2020Article
- Predictive and Prognostic Factors of Synchronous Colorectal Lung-Limited Metastasis.Gastroenterology research and practice · 2020Article
- Survival and analysis of prognostic factors for hepatoblastoma: based on SEER database.Annals of translational medicine · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is no conclusion about the most important contributor to the upswing of locally advanced colorectal cancer (LACRC) survival.
methodsData from the Surveillance, Epidemiology, and End Results (SEER) database was extracted to identify colorectal adenocarcinoma cancer patients at stage II and III diagnosed in the two periods 1989-1990 and 2009-2010. The statistical methods included Pearson's chi-squared test, log-rank test, Cox regression model and propensity score matching.
resultsThe Cox regression model showed that hazard ratio (HR) of non-surgery dropped from 11.529 to 3.469 in right colon cancer (RCC), 5.214 to 2.652 in left colon cancer (LCC) and 3.275 to 3.269 in rectal cancer (RC) from 1989-1990 to 2009-2010. The 95% confidence intervals (CIs) for surgical resection in 2009-2010 were narrower than those in 1989-1990. HR became greater in LACRC without chemotherapy (from 1.337 to 1.779 in RCC, 1.269 to 2.017 in LCC, 1.317 to 1.811 in RC). There was no overlapping about the 95% CI of chemotherapy between the two groups. The progress of surgery was not linked to the improvement of overall survival (OS) of RCC (
conclusionsAdvancements in chemotherapy regimen were the main contributor to the upswing of CRC survival. The improvements in surgery had a limited effect on improvements in CRC survival.
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