Evidence map›Paper›PMID 31360058›Full record

ArticleEvolutionary bioinformatics online2019

Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus.

Ke Guo, Li-Li Li, Qing Zhang, Jie-Mei Yu, Yan Ye

Abstract read
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Article in Evolutionary bioinformatics online, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ke GuoDepartment of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Li-Li LiDepartment of Diarrhea, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Qing ZhangDepartment of Diarrhea, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Jie-Mei YuDepartment of Diarrhea, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.ORCID https://orcid.org/0000-0003-2988-384X
Yan YeDepartment of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We assessed the quasispecies heterogeneity of a human astrovirus MLB2 (HAstV-MLB2-YJMGK) in immunocompromised patients following hematopoietic stem cell transplantation and performed genetic and evolutionary analyses of HAstV isolates circulating worldwide. The result showed that the virus had diversified variants and a strong positive selection in the patient, indicating that such patients may be a reservoir for astrovirus. The time to the most recent common ancestor of MLB2 and classic HAstVs was around 1800 years, and it has a decline in effective population size of HAstVs in the late 100 years.

Indexed as

hematopoietic stem cell transplantationhuman astrovirusmolecular evolutionquasispecies

Identifiers

PMID31360058
PMCPMC6637835

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