Evidence map›Paper›PMID 31360025›Full record

ArticleJournal of clinical and experimental hepatology

Left Ventricular Diastolic Dysfunction is Associated with Renal Dysfunction, Poor Survival and Low Health Related Quality of Life in Cirrhosis.

Madhumita Premkumar, Devaraja Devurgowda, Tanmay Vyas, Saggere M Shasthry, Jelen S Khumuckham, Ritu Goyal, Sherin S Thomas, Guresh Kumar

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06095466 (Diagnosis and Pathogenetic Mechanisms in Cirrhotic Cardiomyopathy Based on Point-of-care Echocardiography, Biomarkers and Histology), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06095466 recruitingnot on this map

Diagnosis and Pathogenetic Mechanisms in Cirrhotic Cardiomyopathy Based on Point-of-care Echocardiography, Biomarkers and Histology

TypeobservationalSponsorPost Graduate Institute of Medical Education and Research, ChandigarhRan2023 to 2026Enrolled150ConditionsCirrhotic Cardiomyopathy, Cirrhosis, Liver, Cardiac DiseaseArmsEchocardiographic assessment, Histopathology and Immunohistochemistry
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Pathogenic Mechanisms Underlying Cirrhotic Cardiomyopathy.Frontiers in network physiology · 2022
    Review
  13. Review
  14. Exercise Training Attenuates Cirrhotic Cardiomyopathy.Journal of cardiovascular translational research · 2021
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Diagnosis and Management of Cirrhotic Cardiomyopathy.Journal of clinical and experimental hepatology
    Article
  20. Overview of Complications in Cirrhosis.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Madhumita PremkumarDepartment of Hepatology, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi 110070, India.
Devaraja DevurgowdaDepartment of Hepatology, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi 110070, India.
Tanmay VyasDepartment of Hepatology, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi 110070, India.
Saggere M ShasthryDepartment of Hepatology, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi 110070, India.
Jelen S KhumuckhamDepartment of Cardiology, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi 110070, India.
Ritu GoyalDepartment of Biochemistry, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi 110070, India.
Sherin S ThomasDepartment of Biochemistry, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi 110070, India.
Guresh KumarDepartment of Biostatistics, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi 110070, India.
Institute of Liver and Biliary Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe presence of left ventricular diastolic dysfunction (LVDD) in patients with cirrhosis leads to a restriction of activities and a poor health related quality of life (HRQoL), which should be taken into consideration when treating them for liver and cardiac complications.

aimsThe prevalence, complications, predictors of HRQoL and survival in cirrhotic patients with LVDD were studied.

methodsWe report a prospective cohort study of 145 consecutive cirrhotic patients with LVDD who were evaluated for cardiac functional status at enrollment and followed up for hepatic complications, cardiac events, outcome and HRQoL using the Minnesota Living With Heart Failure Questionnaire (MLHFQ) over a period of 2 years.

resultsIn total, 145 (mean age 61 years, 59% male) patients were included. Seventeen patients died with 10.5%, 22.5% and 40% mortality rates in patients with Grades 1, 2 and 3 LVDD respectively over 24 months. The parameters that were significant for predicting mortality on bivariate analysis were MELD, MELDNa, hepatic venous pressure gradient, MLHFQ, and left ventricular (LV) diastolic function (e' and E/e' ratio), but only MELD, MELDNa and E/e' remained significant on multivariate analysis. The E/e' ratio (8.7 ± 3.3 in survivors vs. 9.1 ± 2.3 in non-survivors) predicted outcome. On univariate analysis, the predictors of poor HRQoL were the Child-Pugh score ≥9.8 (OR 2.6; 95% confidence intervals (CI) 2.3-9.1,

conclusionThe grade of LVDD correlates with liver function, clinical events, risk of renal dysfunction and HRQoL. Evaluation of novel therapies which target symptomatic improvement in LVDD, should be done with suitable outcome measures, including HRQoL assessment.

Indexed as

2D, two-dimensionalA, atrial wave-filling peakASE, the American Society of EchocardiographyAUC, area under the curveBNP, brain natriuretic peptideCI, confidence intervalcirrhosiscirrhotic cardiomyopathyCO, cardiac outputDT, deceleration timeE/A, early diastolic mitral inflow velocity/late diastolice′, early diastolic mitral annular velocityE/e′ ratio, E-wave transmitral/early diastolic mitral annular velocityE, E-wave transmitral peak early fillingFHVP, free hepatic venous pressureGI, gastrointestinalHealth related Quality of LifeHeart FailureHE, hepatic encephalopathyHR, heart rateHRS, hepatorenal syndromeHVPG, hepatic venous pressure gradientIVRT, isovolumetric relaxation timeleft ventricular diastolic dysfunctionLT, liver transplantationLVDD, left ventricular diastolic dysfunctionLVEF, left ventricular ejection fractionLV, left ventricularMAP, mean arterial pressureMELD, Model for End-Stage Liver DiseaseMLHFQ, Minnesota Living with Heart Failure questionnaireOR, Odds RatioPAP, pulmonary artery pressurePCWP, pulmonary capillary wedged pressurePH, portal hypertensionRAP, right atrial pressureRR, relative riskSBP, spontaneous bacterial peritonitisSD, standard deviationTDI, tissue Doppler imagingTIPS, transjugular intrahepatic portosystemic shuntTTE, transthoracic echocardiographyUSG, ultrasonographyWHVP, wedged hepatic venous pressures

Identifiers

PMID31360025
PMCPMC6637070
OpenAlexW2889220967

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.