Evidence map›Paper›PMID 31359629›Full record

Trial reportMolecular genetics & genomic medicine2019

Correlation of EYS polymorphisms with lumbar disc herniation risk among Han Chinese population.

Demin Ji, Wenhua Xing, Feng Li, Zhi Huang, Wenkai Zheng, Baoyang Hu, FangLin Niu, Yong Zhu, Xuejun Yang

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Incidence of and risk factors for lumbar disc herniation with radiculopathy in adults: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Demin JiInner Mongolia Medical University, Hohhot, China.
Wenhua XingThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Feng LiThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Zhi HuangThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Wenkai ZhengThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Baoyang HuInner Mongolia Medical University, Hohhot, China.
FangLin NiuKey Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China.
Yong ZhuThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Xuejun YangThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.ORCID 0000-0001-6300-2474
Second Affiliated Hospital of Inner Mongolia Medical University · CNMinistry of Education of the People's Republic of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLumbar disc herniation (LDH) is a common spinal disease in clinical practice. Once lumbar disc herniation occurs, it seriously reduces patient's quality of life. The EYS (eyes shut homolog) was discovered in recent years and it may be related to lumbar disc herniation. So we conducted a case-control study to explore the relationship between EYS polymorphism and lumbar disc herniation risk.

methodsWe selected 5 single-nucleotide polymorphisms (SNPs) of EYS gene in a case-control study with 508 cases and 508 healthy controls to evaluate the relatedness by using genetic model, haplotype, and stratification analysis.

resultsWe found that the minor alleles of rs62413038 (OR = 1.21, 95%CI: 1.01-1.43, p = .036) and rs9450607 (OR = 1.26, 95% CI: 1.05-1.53, p = .016) were associated with an increased risk of lumbar disc herniation in the allelic model analysis. In the genotypic model analysis, rs62413038 displayed a significantly increased risk of lumbar disc herniation in log-additive models (OR = 1.20, 95% CI: 1.01-1.43, p = .039). While the rs9450607 was also obviously associated with an increased lumbar disc herniation risk in recessive (OR = 1.98, 95% CI: 1.24-3.13, p = .004) and log-additive models (OR = 1.27, 95% CI: 1.05-1.55, p = .014). In addition, in the haplotype analyses of the SNPs, we found that the "CGGA" haplotype of rs1482456, rs9342097, rs9450607, and rs7757884 was associated with lumbar disc herniation. (OR = 0.52, 95% CI: 0.30-0.89, p = .017).

conclusionThese results suggest that EYS polymorphism may be associated with lumbar disc herniation among Han Chinese population. It also opens up a new exploration direction for the etiology of lumbar disc herniation.

Indexed as

Asian PeopleIntervertebral Disc DegenerationIntervertebral Disc DisplacementModels, GeneticPolymorphism, Single NucleotideAdultChinaEye ProteinsFemaleHumansMaleMiddle AgedEye ProteinsEYS protein, humanCase-control studyEYSLumbar disc herniation (LDH)Single-nucleotide polymorphism (SNP)

Identifiers

PMID31359629
PMCPMC6732306
OpenAlexW2964973856

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.